Advanced Breast Cancer Therapies

Moved, week to 23 Oct 2026: 1
Papers in 60 days: 8

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Switching to camizestrant at ESR1 mutation emergence before disease progression during first-line treatment of hormone receptor-positive advanced breast cancer (SERENA-6): extended analysis of a double-blind, placebo-controlled, randomised, phase 3 trial.
The Lancet Oncology · 1 Aug 2026 · Randomized Controlled Trial
Switching to camizestrant at ESR1 mutation emergence during first-line therapy significantly extends progression-free survival in hormone receptor-positive advanced breast cancer, with a median of 16.8 months.
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Talazoparib plus enzalutamide in high-volume metastatic hormone-naive prostate cancer: a randomized phase 2 trial.
Nature Medicine · 14 Oct 2026 · Journal Article
Talazoparib plus enzalutamide achieved a 73% PSA <0.2 ng/ml response rate at 12 months in high-volume metastatic hormone-naive prostate cancer, exceeding efficacy thresholds.
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CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.
Cancer Research · 2 Oct 2026 · Journal Article
CDK2 inhibitor PF-07104091 achieves disease stabilization in CDK4/6 inhibitor-resistant HR+/HER2- metastatic breast cancer regardless of RB status, with responses linked to TP53 retention.
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A breakthrough in p53-targeted therapy.
Nature Cancer · 1 Oct 2026 · Journal Article
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Quantitative Systems Pharmacology Model for Trop-2 Targeting Antibody-Drug Conjugate in Triple-Negative Breast Cancer
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752985
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Liu Y, Chen Q, Jeong H-W, et al. Dopamine signaling regulates hematopoietic stem and progenitor cell function. Blood. 2021;138(21):2051-2065.
Blood · 17 Sept 2026 · Journal Article
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Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer.
Genome Research · 1 Sept 2026 · Journal Article
Genomic features controlling ESR1 binding and activity differ between endometrial and breast cancer, with SOX17 uniquely regulating ESR1 in endometrial cancer.
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Adaptive mechanisms and emerging cancer therapeutics for CDK2 inhibitors.
Nature Chemical Biology · 31 Aug 2026 · Review
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https://jclub.com.au/a/42675128
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Systematic analysis of network-driven adaptive resistance to CDK4/6 and oestrogen receptor inhibition using meta-dynamic network modelling.
eLife · 27 Aug 2026 · Journal Article
Heterogeneity in protein signalling networks, especially reaction coefficients, drives adaptive resistance to CDK4/6 and oestrogen receptor inhibitors, as shown by MDN modelling.
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