Human Argonaute 2 fused to a C-to-U deaminase achieves 1.9-fold higher targeted RNA editing in HEK293T cells compared to Cas13-based editors.
- Open access
RNA regulation and disease
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EMB1417 is essential for chloroplast RNA editing at multiple sites and intron splicing in Arabidopsis, with disruption causing a yellow-leaf phenotype and reduced chlorophyll.
A decade after their discovery in 2016, base editors have evolved into versatile tools used in clinical trials for multiple human diseases, including sickle cell disease and leukaemias.
Corrected splicing metrics reveal distinct NMD-sensitive and NMD-evading transcript classes with improved accuracy from short-read RNA-seq data.
- Open access
cPRIME enables endogenous mapping of genetic variant effects at RNA level, revealing that synonymous marker edits can alter RNA processing in diverse genomic contexts.
- Open access
Calibrated nanopore DRS analysis reveals cell-specific m6A proportions at conserved sites, with Dorado predictions capturing increasing GLORI site proportions at high m6A/A levels.
- 2 cites
Adenine base editing successfully generated a PKP2 c.1171-2 A>G mutant human embryonic stem cell line, WAe009-A-3W, with preserved pluripotency and normal karyotype.
- Open access
Highly efficient retron-based gene editors for mammalian cells and vertebrates achieve editing levels comparable to conventional methods using a genetically encoded cassette.
- 7 cites
NCBP1 stress signaling induces alternative splicing of over 250 genes, including S6 kinase, which inhibits global protein translation in the nucleus.
- Open access
- 1 cites
Secondary structure in target RNAs inhibits Cas13 activity, but strand displacement can enhance mismatch discrimination up to 50-fold in cellular environments.
- Open access
- 19 cites
PKP1 suppresses keratinocyte innate immune responses by sequestering DExD/H helicases, preventing excessive inflammation in healthy skin cells.
- Open access
Viral delivery of PRPF31 restores splicing, cellular function, and visual activity in patient-derived retinal cells, even in mature stages, offering a promising therapy for RP11.
- Open access
DIS3's 3'-5' exoribonucleolytic activity is essential for resolving backtracked transcription complexes in Homo sapiens, facilitating efficient RNA polymerase II elongation.
- Open access
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Topics moving, week to 23 Oct 2026
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