Genetic code expansion enables plant-specific control of bacterial protein synthesis using O-methyl-L-tyrosine in soil bacteria.
- Open access
Nature Biotechnology
Nature Portfolio · Genomics & Bioinformatics · ISSN 1087-0156, 1546-1696
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Human Argonaute 2 fused to a C-to-U deaminase achieves 1.9-fold higher targeted RNA editing in HEK293T cells compared to Cas13-based editors.
- Open access
HitSV improves structural variant detection accuracy by 15-72% across sequencing technologies and expands SV callsets by 31.5% in human cohorts.
Ligand-directed lipid nanoparticles achieve up to 80% in vivo transfection of NK cells and enable effective CAR NK cell generation in mice.
Shotgun genetic engineering enables screening of millions of mammalian pathway combinations, achieving amino acid biosynthesis with tens of kilobases of synthetic DNA.
Visionary AI predicts preeclampsia with an AUC of 0.91 in a cohort of 1,267 pregnancies using retinal imaging and vascular modeling.
Engineered avian R2 retrotransposons achieve up to 60% site-specific gene integration in human primary cells.
Detectrons convert transient RNA sequences into stable DNA barcodes, enabling high-throughput analysis of RNA-dependent processes in living cells.
Inhalable BEAT exosomes co-displaying PD-1 and FZD8 activate T cells and produce robust antitumor effects in ICI-resistant melanoma mouse models.
- Open access
- 4 cites
A single-chain antibody derivative of TS2/16 enhances gastrointestinal organoid yield up to fivefold in Matrigel and six- to sevenfold in collagen I hydrogels.
- Open access
- 16 cites
Deep-learning-based genetic perturbation models outperform uninformative baselines on calibrated metrics across 14 datasets and 18 measures.
- Open access
Highly efficient retron-based gene editors for mammalian cells and vertebrates achieve editing levels comparable to conventional methods using a genetically encoded cassette.
- 7 cites
Antibody–lectin chimeras (AbLecs) outperform conventional antibody therapies in enhancing antitumor immune responses in cancer models.
- Open access
CellWhisperer enables chat-based exploration of single-cell RNA-sequencing data with zero-shot prediction accuracy demonstrated in human embryonic development.
- Open access
- 35 cites
A Postn+ mesenchymal cell subset is essential for T lymphopoiesis and thymus regeneration, and its transfer enhances T cell production and immune response.
- Open access
- 16 cites
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