F-actin up-regulation in Pardosa pseudoannulata under cadmium exposure activates Hippo pathway suppression of Yki, revealing a regulatory mechanism in spider cadmium toxicity.
Hippo pathway signaling and YAP/TAZ
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Lysosomal stress activates a TBK1/ULK1 pathway that inhibits FLCN and promotes TFEB-driven tumor growth, with mutations in v-ATPase amplifying this effect.
VGLL4 promotes MAFLD progression by enhancing PDK4 transcription, with hepatocyte-specific overexpression inducing steatosis and knockout protecting mice from metabolic dysfunction.
- Open access
YAP1 induces hepatocellular carcinoma through DNA demethylation, not canonical driver gene mutations, with widespread demethylation activating oncogenes in mouse models.
- Open access
SEPTIN7 promotes hepatocellular carcinoma progression and therapy resistance by stabilizing FGFR4 and enhancing its recycling, with knockout suppressing tumor development.
- Open access
Centrosome migration and apical membrane formation are hierarchically related but can occur independently during epithelial polarization in MDCK cysts, with centrosome positioning influenced by Par3.
- Open access
Exclusion of aPKC from the apical cortex in enteroblasts prevents overproliferation of intestinal stem cells in Drosophila midgut, maintaining tissue homeostasis.
Hedgehog signaling drives exponential growth and neuronal production in the developing vertebrate retina by regulating neural progenitor cell cycles.
- Open access
- 1 cites
Activation of YAP/TAZ in bone marrow niche cells accelerates hematopoietic regeneration after myeloablative stress.
- Open access
- 1 cites
Impairing autophagy in the Drosophila mushroom body triggers brain-wide presynaptic remodeling and enhances resilience, including increased sleep and lifespan.
- Open access
Draper-Src-Shark signalling in Drosophila intestinal stem cells detects tissue damage and drives proliferation, essential for midgut regeneration.
- Open access
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