PARP inhibition in cancer therapy

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Talazoparib plus enzalutamide in high-volume metastatic hormone-naive prostate cancer: a randomized phase 2 trial.
Nature Medicine · 14 Oct 2026 · Journal Article
Talazoparib plus enzalutamide achieved a 73% PSA <0.2 ng/ml response rate at 12 months in high-volume metastatic hormone-naive prostate cancer, exceeding efficacy thresholds.
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More than just a passive brick in the wall: the nucleosome facilitates DNA polymerase β activity in linker DNA and its PARP-dependent regulation in the BER sub-pathway choice
bioRxiv · 13 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.12.705504
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Pharmacologically targeting CDK12 induces BRCAness and synergizes with merestinib to exacerbate DNA damage in high-risk neuroblastoma.
Cell Reports · 12 Oct 2026 · Journal Article
Inhibition of CDK12 induces BRCAness and apoptosis in neuroblastoma cells, with OKI-1546 reducing tumor growth and extending survival in vivo.
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Behavioral, Cardiovascular, and Neuroinflammatory Effects of 3-Aminobenzamide in a Rodent Model of Chronic Psychological Stress
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.28.721400
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Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment induces PARPi resistance in epithelial ovarian cancer through p300-dependent mechanisms.
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https://jclub.com.au/a/42467549
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DNA end-resection is stimulated by an interaction between BRCA1 exon 11 and TOPBP1.
EMBO Reports · 1 Oct 2026 · Journal Article
Interaction between BRCA1 exon 11 and TOPBP1 is essential for DNA end-resection during homologous recombination.
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Patient-derived separation-of-function mutations reveal specific role for BRCA1 coiled coil domain in genome stability.
Nature Communications · 22 Sept 2026 · Journal Article
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Mechanisms and disease relevance of DNA break repair pathway choice.
Nature Reviews Molecular Cell Biology · 18 Sept 2026 · Review
DNA repair pathway choice between homologous recombination and non-homologous end joining is regulated by DNA end resection and specific repair factors.
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Yeast Rad55-Rad57-SHU paralog complex dynamically promotes Rad51 filament formation.
Molecular Cell · 17 Sept 2026 · Journal Article
Yeast Rad55-Rad57-SHU complex promotes Rad51 filament formation through a dual-nucleotide regulatory mechanism.
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PARG Governs a PARylation-Ubiquitination Toggle that Stabilizes RAD51AP1 to Drive Homologous Recombination-Mediated Chemoresistance.
Cancer Research · 15 Sept 2026 · Journal Article
PARG stabilizes RAD51AP1 through a PARylation-ubiquitination switch, promoting homologous recombination repair and contributing to chemoresistance in gastric cancer.
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HDAC2 inhibition restores H4K16ac and delays senescence in HGPS VSMCs
bioRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.07.687234
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DNA damage repair gene defects combined predict the efficacy of immune checkpoint inhibitors in metastatic castration-resistant prostate cancer: a retrospective cohort study.
Frontiers in Genetics · 1 Sept 2026 · Journal Article
Combined DDR gene mutation profiling with TMB and PD-L1 predicts immunotherapy response in 152 metastatic castration-resistant prostate cancer patients, with an AUC of 0.83.
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Next-generation cancer therapeutics.
Nature Cancer · 1 Sept 2026 · Editorial
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