Elevated TFAM expression in dendritic cells is linked to poor response to neoadjuvant immunochemotherapy in residual ESCC.
Immune cells in cancer
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Latest in Immune cells in cancer
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Activating PPARδ in immune cells enhances tumor suppression and improves immunotherapy responses in mice with metastatic colorectal cancer.
- Open access
Myeloid-specific Tet2 deletion generates myeloid-derived activating cells that enhance radiotherapy and suppress metastasis in lung cancer models.
IL-1α promotes expansion of SLC2A1highSPP1highIFNlow myeloid cells that drive immune escape and malignant transformation in precancerous head and neck lesions.
Macrophage-induced IL1B-IL1R1 signaling promotes senescent CAFs that mediate chemoresistance in colorectal cancer.
Blocking the m(6)Am methyltransferase PCIF1 in macrophages reduces colitis progression and protects enteric neurons from inflammation-driven degeneration.
Neutrophil-integrated syncytial CAR macrophages significantly enhance tumor infiltration and reduce tumor burden in mouse models of cancer.
PLA2G2D in tumour-draining lymph nodes acts as a novel immune checkpoint that suppresses anti-tumour T cell responses, with inhibition reducing tumour growth in melanoma models.
- Open access
A senescent-like neutrophil subset marked by BHLHE40 is enriched in colorectal cancer liver metastasis and linked to poor prognosis.
Restoring IL-17D in glioblastoma reprograms CD93(+) antigen-presenting cells, extending survival by activating immune responses in mouse models.
Cancer-associated extracellular vesicles and particles are linked to widespread systemic dysfunction across multiple organs, contributing to host morbidity and mortality.
LPL-positive endothelial cells promote intratumoral CD8+ T-cell homing and liver metastasis regression by enhancing antigen presentation.
- Open access
Neutrophils in pancreatic cancer liver metastases take up tumor fragments via trogocytosis and modulate macrophages through C3-dependent signaling, limiting immunosuppressive macrophage development.
- Open access
Uterine monocytes have dual roles in tissue remodeling and inflammation, with their numbers peaking before embryo implantation in humans.
- Open access
Exercise reduces stromal fibroblasts and inflammatory signals in pancreatic cancer, with a 50% decrease in αSMA+ cells linked to microbial metabolites.
- Open access
Type 2 immune history induces lung macrophages that confer viral disease tolerance, with 100% survival in previously infected mice challenged with lethal influenza.
- Open access
A 7-gene M2 macrophage-associated signature predicts osimertinib resistance in lung adenocarcinoma, with RRBP1 showing the strongest link to survival.
- Open access
Elevated extracellular fluid viscosity in the tumor microenvironment promotes M2-like macrophage polarization, breast cancer growth, metastasis, and resistance to immunotherapy.
- Open access
Acetate inhibits esophageal squamous cell carcinoma growth by activating an ACSS2-dependent H2A.Z acetylation pathway, with low acetate and ACSS2 linked to poor prognosis.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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