Telomeres, Telomerase, and Senescence

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Beyond ERCs: exploring catastrophic forms of rDNA instability in aging yeast
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.21.719800
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Establishment of a doxycycline-inducible p16(INK4a) knock-in human embryonic stem cell line, WAe009-A-3Y.
Stem cell research · 9 Oct 2026 · Journal Article
A doxycycline-inducible p16 INK4a knock-in human embryonic stem cell line was established, showing dose-dependent p16 INK4a and ZsGreen expression upon induction.
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https://jclub.com.au/a/42880101
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Oxidative DNA damage drives centromere fragility and chromosome instability.
Cell Reports · 9 Oct 2026 · Journal Article
Oxidative DNA damage at centromeres promotes chromosome instability, with lesions leading to DNA breaks and aneuploidy in pre-tumorigenic cells.
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DNA polymerase kappa supports repair-associated DNA synthesis and neuronal genome resilience
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.01.756094
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A Measure of Transcriptional Dyscoordination for Quantifying Aging in Single Cells
bioRxiv · 7 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.24.701460
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Turning aging cells into a live vaccine: engineered senescent cancer cells with adjuvant celecoxib for immunotherapy
bioRxiv · 6 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.15.694320
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Generation of inducible LMNA and Progerin hiPSC lines for controlled modelling of cellular ageing.
Stem cell research · 5 Oct 2026 · Journal Article
Inducible hiPSC lines with controlled Progerin expression enable modeling of cellular aging, with successful integration confirmed by PCR and sequencing.
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https://jclub.com.au/a/42868746
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Blood cell composition reveals distinct biological interpretation of DNA methylation age and age acceleration.
Genome Medicine · 2 Oct 2026 · Journal Article
Blood cell composition accounts for up to 53% of variation in DNA methylation age, with a strong influence from naїve and memory T cell balance.
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Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.
Cancer Research · 2 Oct 2026 · Journal Article
Macrophage-induced IL1B-IL1R1 signaling promotes senescent CAFs that mediate chemoresistance in colorectal cancer.
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Goals and challenges for senescence research.
Nature Cell Biology · 1 Oct 2026 · Journal Article
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Calorie restriction reduces somatic mutation burden in mice.
Nature Genetics · 1 Oct 2026 · Journal Article
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Single-stranded telomeric repeats segregate into spatial compartments within ALT-associated PML bodies
bioRxiv · 30 Sept 2026 · Preprint
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Gap-free telomere-to-telomere haplotypes assembly of the hybrid grouper 'Yushuban' (Cromileptes altivelis female x Epinephelus fuscoguttatus male)
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.20.752973
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Lactate Receptor Activation Alleviates Senescence and Preserves Homeostasis of Aged Arteries
bioRxiv · 25 Sept 2026 · Preprint
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Tissue-specific aging-a new paradigm based on transcriptional insights from select model systems and humans.
Frontiers in Genetics · 22 Sept 2026 · Review
Tissue-specific aging patterns are revealed through transcriptomic analysis across multiple model systems and humans, indicating that each tissue ages differently.
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A generator-matrix model quantifies the limited contribution of measured biomarkers to human mortality acceleration
medRxiv · 18 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.05.26356402
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Skin commensals shape the clock-ferroptosis axis to preserve barrier function in psoriasis.
Cell Reports · 17 Sept 2026 · Journal Article
Lactobacillus plantarum and its metabolite indole-3-lactic acid restore skin barrier function by modulating the clock-ferroptosis axis in psoriasis.
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Senescent cell heterogeneity in brain aging and neurodegenerative disease.
Neuron · 16 Sept 2026 · Review
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https://jclub.com.au/a/42480535
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Quantitative proteomics reveals coordinated changes in the proteome during replicative senescence.
Nature Communications · 16 Sept 2026 · Journal Article
Proteome changes during replicative senescence are highly coordinated, with widespread chromatin protein depletion and increased mitochondrial insolubility, affecting cellular function.
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Complete Telomere-to-Telomere Assembly of the Y Chromosome in the Chinese Quartet
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.13.718326
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The impact of chronic exposure to cigarette and waterpipe smoke extracts on telomeres, telomerase, and cancer progression.
Frontiers in Genetics · 9 Sept 2026 · Journal Article
Chronic exposure to cigarette and waterpipe smoke extracts causes telomere shortening and increases telomerase activity, promoting cancer progression in lung, colon, and breast cancer cells.
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https://jclub.com.au/a/42775372
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Telomere variant sequences encode the genetic blueprint for allele-specific telomere length.
Nature Communications · 7 Sept 2026 · Journal Article
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https://jclub.com.au/a/42838939
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Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.
Nature Biotechnology · 7 Sept 2026 · Journal Article
Six proteomic aging clocks consistently predicted lower biological age in a 12-week clinical trial of rentosertib for idiopathic pulmonary fibrosis.
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https://jclub.com.au/a/42706338
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Fragmentation patterns of human telomeric chromatin in plasma cfDNA.
Nature Communications · 4 Sept 2026 · Journal Article
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https://jclub.com.au/a/42834070
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Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity.
Nature Communications · 4 Sept 2026 · Journal Article
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Age-associated erosion of organ-specific endothelial programs compromises tissue function and resilience
bioRxiv · 3 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.02.735775
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The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging.
Cell Metabolism · 1 Sept 2026 · Review
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Convergence and conflict among telomere-specialized transposons across 60 million years of Drosophilid evolution.
Genome Research · 1 Sept 2026 · Journal Article
Drosophila telomere transposons have repeatedly lost, gained, and horizontally transferred genes over 60 million years, showing dynamic convergent evolution and conflict with hosts.
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https://jclub.com.au/a/42386527
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The unbearable presence of senescent cells in ageing.
Nature Reviews Genetics · 1 Sept 2026 · Journal Article
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Telomere-to-Telomere Accurate and Gapless Korean Standard Reference Genome
bioRxiv · 31 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.17.688257
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