Orphan yeast septins are stabilized by coiled-coil homodimers, trimers, and the disaggregase Hsp104, preventing aggregation and proteasomal degradation.
- Open access
Heat shock proteins research
Moving in bioRxiv, Plant Physiology and Biochemistry, EMBO Reports, Journal of Experimental Botany, Cell, EMBO Journal, Frontiers in Genetics and Fungal Biology.
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Latest in Heat shock proteins research
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Tryptoline acrylamide stereoprobes can disrupt the GRPEL1-HSPA9 complex by targeting nonorthosteric sites, impairing mitochondrial protein import and mitophagy.
- Open access
- 1 cites
A PebZIP44-PeHSF12-PeHSP17.8 transcriptional module regulates heat shock protein expression and enhances thermotolerance in passion fruit.
- Open access
SpHsfA3a/b directly regulate SpHSP26.5-1/-2 and enhance heat stress resistance in Sorbus pohuashanensis.
- Open access
Repeated heat waves induce divergent transcriptional responses in cold- and warm-adapted Saccharomyces yeast species, with species-specific memory-like gene regulation patterns.
- Open access
CMA regulates a broad range of physiological functions and its dysfunction in ageing and disease causes cellular changes beyond damaged protein accumulation.
Larval-stage protein restriction reduces Lsp2 expression, decreases ribosomal proteins, and extends adult lifespan in Drosophila.
- Open access
- 2 cites
Silencing SsUBA52 in Sclerotinia sclerotiorum increases pathogenicity and alters development, with silenced strains showing more compound appressoria and higher infection capability.
FBXL21 regulates diurnal proteostasis in skeletal muscle by mediating degradation of DNAJB6 and its client proteins, including Desmin and TDP-43.
- Open access
HSP70 depletion in HeLa cells causes over 90% reduction in transcript and protein levels, leading to a 1.8-fold increase in misfolded/aggregated proteins.
- Open access
Cancer cells in breast tumors exploit LACTB's autoproteolytic activity, leading to its self-degradation and inactivation, with LACTB's activity modulated by increased MRPS34 levels.
- Open access
Cytoplasmic AtHsp18.5 enhances drought and lead tolerance in Arabidopsis thaliana by acting as a molecular chaperone and regulating stress-responsive genes.
- Open access
RsHSFA3 enhances heat tolerance in Rhododendron simsii by activating heat shock proteins and improving ROS scavenging capacity.
- Open access
Chloroplasts utilize a RAF3/6 kinase module to coordinate energy production and stress responses during cold stress, with RAF6 variation linked to cold adaptation.
NtEPF3 and NtEPFL6 peptides enhance drought tolerance in tobacco by regulating stomatal function and kinase signaling pathways.
- Open access
Genomics and biotechnology advances have identified key genetic loci and mechanisms that enable wheat to tolerate heat stress, accelerating breeding for climate resilience.
- Open access
FAF1 and FAF2 significantly boost p97-UFD1-NPL4 complex activity, increasing substrate unfolding efficiency by engaging key cofactors and conserved activation motifs.
- Open access
A novel ~25 kDa isoform of PANX1, expressed in mouse melanoma cells, interacts with full-length PANX1 and is prevalent in cancer progression.
- Open access
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Topics moving, week to 23 Oct 2026
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