Amyotrophic Lateral Sclerosis Research
Moving in bioRxiv, medRxiv, Stem cell research, Cell Reports, Gastroenterology, Blood, Cell and eLife.
- Moved, week to 23 Oct 2026
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- Papers in 60 days
- 39
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Latest in Amyotrophic Lateral Sclerosis Research
Newest first · last 60 days
Reducing ataxin-2 activates stress-adaptive metabolic pathways in neurons and astrocytes, providing broad protection against TDP-43 toxicity in ALS models.
- Open access
High NPM1 variant allele frequency (VAF) above 31.44% predicts better survival in NPM1-mutated AML patients.
- Open access
Cytoplasmic TDP-43 gain-of-function causes splicing abnormalities linked to ALS, FTLD, and AD, including APP isoform disruption, across all three diseases.
- Open access
- 6 cites
Two iPSC lines from ALS patients with mutations in SQSTM1 and TBK1 genes were successfully established and characterized.
- Open access
Single-cell APA profiling in the human brain reveals 3'aQTLs linked to 17 GWAS loci, including key genes for Alzheimer's, schizophrenia, and Parkinson's disease.
- Open access
Tau filaments from human Alzheimer's and corticobasal degeneration brains propagate in mice, maintaining their distinct structures and supporting prion-like transmission.
- Open access
- 1 cites
Embryonic mouse skeletal motor neurons lose transcriptional diversity and re-diversify into adult subtypes to support functional maturation, with 70+ embryonic subclusters consolidating into distinct adult identities.
- Open access
Loss of interruption in the HTT CAG repeat correlates with increased somatic expansions and significant loss of medium spiny neurons in Huntington's disease.
- Open access
Inhibition of nuclear export reduces pathogenic TDP-43 aggregation and phospho-TDP-43 accumulation in ALS models, highlighting nuclear transport as a key modulator.
- Open access
Recurrent TOP1-mediated neuronal genomic damage occurs in over 60% of neurons across ALS, FTD, and AD, linking mutagenesis to neurodegeneration.
- Open access
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Journals this month
- bioRxiv6131
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- Sci Adv354
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- Environ Res230
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- Science141
- Nature138
- Lancet128
- Cell Rep120
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- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3