Pancreatic function and diabetes

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Role of GLP1-receptor signaling and α-β-cell communication in functional β-cell heterogeneity.
bioRxiv · 16 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.25.650736
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Mesodermal-niche interactions direct specification and differentiation of pancreatic endocrine cells in human multilineage organoids
bioRxiv · 12 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.13.694117
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Targeting Lysosomal MCOLN1/TRPML1 Ion Channels to Alleviate Diabetes Mellitus via a Ca2+- CaMKKβ-AMPK pathway
bioRxiv · 12 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.16.732532
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A prioritized medium-throughput screen identifies fibroblast growth factors as protective for human stem cell derived insulin secreting beta cells
bioRxiv · 11 Oct 2026 · Preprint
FGF4, FGF5, FGF8F, FGF19, and FGF21 significantly enhance survival of human stem cell-derived insulin-secreting beta cells, with FGF4 and FGF5 showing the strongest effects.
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https://jclub.com.au/a/10.1101/2025.02.12.637990
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A surviving beta cell subpopulation enriched in patients with T1D
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.15.725449
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The G protein-coupled receptor GPR31 governs inflammatory signaling in the pancreatic islet microenvironment
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.02.680021
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A high-throughput assay for the measurement of Ca(2+) oscillations and insulin release from uniformly sized mouse β-cell (MIN6) spheroids.
eLife · 5 Oct 2026 · Journal Article
A scalable 3D β-cell spheroid platform enables real-time measurement of Ca(2+) oscillations and insulin release in response to glucose and modulators.
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https://jclub.com.au/a/42832264
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Precancerous evolution in pancreas.
Nature Cell Biology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42855534
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Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer.
Cancer Discovery · 1 Oct 2026 · Journal Article
Asynchronous evolution of epithelial and stromal components distinguishes PanIN progression to pancreatic cancer, with stromal reprogramming being notably absent in early lesions.
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https://jclub.com.au/a/42165710
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HnRNPK restrains memory precursor and plasma cell differentiation to control germinal center B-cell output.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
HnRNPK deficiency in germinal center B cells markedly increases plasma cell differentiation and reduces germinal center B-cell numbers by up to 50%.
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https://jclub.com.au/a/42706436
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Predictive control of human pancreatic cell fate using a digital model of in vitro differentiation
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.27.721124
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Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes
bioRxiv · 17 Sept 2026 · Preprint
Inhibiting the Na+ channel gene Scn9a reduces beta cell loss and diabetes incidence in NOD mice, highlighting its potential as a therapeutic target for type 1 diabetes.
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https://jclub.com.au/a/10.1101/2023.06.11.544521
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SLC4A7/NBCn1 maintains intracellular pH to support mTORC1 activity and antibody-secreting cell differentiation.
Nature Communications · 11 Sept 2026 · Journal Article
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https://jclub.com.au/a/42823451
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The metabolic road from α-cells to β-cells.
Nature Chemical Biology · 9 Sept 2026 · Journal Article
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https://jclub.com.au/a/42717053
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Understanding development and cellular plasticity in the pancreas in health and disease.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Review
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https://jclub.com.au/a/42129457
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Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Annals of Internal Medicine · 1 Sept 2026 · Journal Article
Methodological approaches like pragmatic clinical trials and target trial emulation are emphasized as strategies to improve real-world evidence for GLP-1 receptor agonists.
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https://jclub.com.au/a/42372277
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Donor-derived CD8+CD122+ Tregs generated in mixed donor chimeric NOD mice suppress autoreactive T cells
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.20.712252
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