Nature reviews. Gastroenterology & hepatology
Nature Portfolio · Clinical Medicine · ISSN 1759-5045, 1759-5053
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Latest in Nat Rev Gastroenterol Hepatol
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Primary cilia on cholangiocytes act as sensors that regulate biliary homeostasis and are linked to biliary ciliopathies with cystic lesions, fibrosis, and strictures.
Synthetic data generation has the potential to transform gastrointestinal medicine by enabling more effective prevention, diagnosis, and treatment strategies.
CD19-targeted CAR T cell therapy can induce long-term remission of intestinal inflammation in ulcerative colitis, revealing a key role for mucosal B cells and plasmablasts.
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Actin cytoskeletal dynamics are crucial for hepatic myofibroblast activities involved in liver fibrosis.
Molecular, cellular, and functional organization of nutrient absorption varies regionally along the small intestine, with a comprehensive framework now emerging to define this zonation.
Exposome research in IBD highlights the importance of environmental factors, including microplastics and nanoplastics, for understanding disease risk and prevention strategies.
Many non-antibiotic compounds exhibit antibacterial activity, often affecting beneficial bacteria more strongly than pathogenic Enterobacteriaceae in humans.
Occult hepatitis B virus infection affects up to 40% of individuals with isolated anti-HBc, with prevalence varying from 0.8% in the general population to over 40% in high-risk groups.
Multidisciplinary heart-liver co-management improves detection and treatment of MASLD, addressing a critical gap in cardiometabolic care with potential to reduce mortality.
Manipulating intestinal stem cells enables the regeneration and repair of human intestines, advancing potential treatments for a wide range of intestinal diseases.
Combining radiotherapy and immunotherapy offers a promising approach to improve survival in localized pancreatic ductal adenocarcinoma, despite current challenges.
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