Pancreatitis Pathology and Treatment

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Moved, week to 23 Oct 2026: 0
Papers in 60 days: 19

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Daraxonrasib in Previously Treated Metastatic Pancreatic Cancer.
New England Journal of Medicine · 22 Oct 2026 · Letter
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Daraxonrasib in Previously Treated Metastatic Pancreatic Cancer. Reply.
New England Journal of Medicine · 22 Oct 2026 · Letter
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HtpG-High-Expressing Escherichia coli Promotes Fibrosis in Chronic Pancreatitis.
Gastroenterology · 13 Oct 2026 · Journal Article
HtpG-high-expressing Escherichia coli (HHEC) is enriched in chronic pancreatitis patients and exacerbates disease via a macrophage-mediated pathway.
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Oleic acid promotes lung injury in hypertriglyceridaemia-associated acute pancreatitis via the PIEZO1/NR4A1/CPT1A axis impairing endothelial fatty acid oxidation.
Gut · 7 Oct 2026 · Journal Article
Elevated plasma oleic acid in hypertriglyceridaemia-associated acute pancreatitis is linked to increased acute lung injury severity via the PIEZO1/NR4A1/CPT1A pathway.
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Chronic Pancreatitis: Mechanisms of Inflammation, Pathways of Progression and Emerging Therapeutic Strategies.
Gastroenterology · 1 Oct 2026 · Review
Chronic pancreatitis involves progressive inflammation and fibrosis, with diagnosis often occurring at advanced stages marked by ductal dilatation or calcification.
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A Clinical Perspective on Comparative Models of Pancreatic Cyst Surveillance.
Gastroenterology · 1 Oct 2026 · Letter
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Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer.
Cancer Discovery · 1 Oct 2026 · Journal Article
Asynchronous evolution of epithelial and stromal components distinguishes PanIN progression to pancreatic cancer, with stromal reprogramming being notably absent in early lesions.
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Multi-stromal organoid co-culture modelling reveals epithelial-fibroblast heterogeneity in pancreatic cancer and pancreatitis.
Nature Cell Biology · 1 Oct 2026 · Journal Article
Distinct epithelial and fibroblast features are identified in pancreatitis and pancreatic ductal adenocarcinoma (PDAC) using multi-stromal organoid co-cultures.
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Inflammation-Induced Claudin-2 Up-Regulation Limits Pancreatitis Development by Enhancing Pancreatic Ductal Transport.
Gastroenterology · 1 Oct 2026 · Journal Article
Up-regulation of CLDN2 in human and mouse pancreatitis models limits disease severity by promoting pancreatic ductal fluid transport.
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Gut complement C1q and C3 interact with Clostridioides difficile spores via CdeM and contribute to pathogenesis.
bioRxiv · 25 Sept 2026 · Preprint
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Pancreatic ductal adenocarcinoma: The Vision of Heracles.
Cancer Cell · 14 Sept 2026 · Journal Article
Targeting multiple overlooked factors, the Heracles Protocol offers a comprehensive approach to make pancreatic ductal adenocarcinoma more treatable.
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The metabolic road from α-cells to β-cells.
Nature Chemical Biology · 9 Sept 2026 · Journal Article
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Pharmacological trials of early intervention in predicted severe acute pancreatitis: implications for therapeutic window and core outcome set.
Gut · 7 Sept 2026 · Letter
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Beyond Pancreatitis: What Primary Endoscopic Ultrasound-Guided Choledochoduodenostomy Means for Surgery and Patient-Centered Outcomes.
Gastroenterology · 1 Sept 2026 · Letter
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ENPP1 as a Risk-Stratification Biomarker to Inform Selective Surveillance in Chronic Pancreatitis.
Gastroenterology · 1 Sept 2026 · Letter
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Understanding development and cellular plasticity in the pancreas in health and disease.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Review
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Pancreatic Duct Stenting and Interpretation of the Endoscopic Retrograde Cholangiopancreatography Comparator Arm in Malignant Distal Biliary Obstruction.
Gastroenterology · 1 Sept 2026 · Letter
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Endoscopic Ultrasound-Guided Choledochoduodenostomy Versus Endoscopic Retrograde Cholangiopancreatography for the Primary Prevention of Pancreatitis: An Unfair Comparison.
Gastroenterology · 1 Sept 2026 · Letter
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KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRAS(G12D)-mutant pancreatic cancer: a phase 1b/2 trial.
Nature Medicine · 1 Sept 2026 · Clinical Trial, Phase I
HRS-4642 combined with chemotherapy achieves a 63.3% objective response rate in advanced KRAS(G12D)-mutant pancreatic cancer, showing promising antitumor activity.
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