Genetics, Aging, and Longevity in Model Organisms

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Multimodal clocks of human aging.
Cell · 9 July 2026 · Journal Article
Multimodal aging clocks accurately quantify human biological age and reveal coagulation factors as key drivers of multi-organ senescence.
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Can GLP-1 drugs slow ageing? Mouse study shows promise.
Nature · 2 Sept 2026 · News
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High-throughput identification of protein turnover modulators in human neurons
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.06.723176
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COMPASS-mediated epigenetic regulation of transcription accelerates forgetting with age
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.31.685883
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Decoupling glycation from mortality: glucose, but not methylglyoxal, reduces survival in zebra finches
bioRxiv · 21 Oct 2026 · Preprint
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Representational geometry as a fidelity metric for connectome-constrained networks: evidence from the Drosophila visual system
bioRxiv · 16 Oct 2026 · Preprint
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RiboTRAP-seq identifies spatially distinct functions for the anterior and posterior intestine in immune and metabolic regulation in Caenorhabditis elegans.
eLife · 16 Oct 2026 · Journal Article
RiboTRAP-seq reveals that anterior INT1 cells in C. elegans intestine are enriched for immune and stress response genes and are crucial for pathogen avoidance and survival.
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Membrane proteomics of the Drosophila circadian neural network
bioRxiv · 14 Oct 2026 · Preprint
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Drosben, an affordable system for scalable survival analysis in Drosophila
bioRxiv · 14 Oct 2026 · Preprint
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Effects of knockdown of autophagy pathway genes on C. elegans longevity are highly condition dependent
bioRxiv · 14 Oct 2026 · Preprint
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Author Correction: p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.
Nature Cell Biology · 12 Oct 2026 · Published Erratum
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Beyond ERCs: exploring catastrophic forms of rDNA instability in aging yeast
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.21.719800
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Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism.
eLife · 8 Oct 2026 · Journal Article
Photo-downregulation of SIRT4 in aged mice increases H3K9ac levels by activating fatty acid metabolism, thereby mitigating cellular aging.
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DNA polymerase kappa supports repair-associated DNA synthesis and neuronal genome resilience
bioRxiv · 8 Oct 2026 · Preprint
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The C. elegans gustatory receptor homolog LITE-1 is a chemoreceptor required for diacetyl avoidance
bioRxiv · 6 Oct 2026 · Preprint
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Two Genomes, One Metabolome: Mitonuclear Incompatibility Remodels Developmental Metabolism and Fitness in Drosophila
bioRxiv · 4 Oct 2026 · Preprint
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Gut Microbiota Fuel Aging Induced by Mitochondrial Dysfunction
bioRxiv · 3 Oct 2026 · Preprint
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Defining the spectrum of cellular protection against cadmium stress by Dsup expressed in yeast
bioRxiv · 3 Oct 2026 · Preprint
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Calorie restriction reduces somatic mutation burden in mice.
Nature Genetics · 1 Oct 2026 · Journal Article
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An evolutionarily conserved N-terminal domain of RRF-3 governs GTSF-1 binding in nematodes.
EMBO Reports · 1 Oct 2026 · Journal Article
GTSF-1 binds to an N-terminal domain of RRF-3 across nematodes, supporting 26G-RNA biogenesis and fertility in Caenorhabditis and related species.
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Goals and challenges for senescence research.
Nature Cell Biology · 1 Oct 2026 · Journal Article
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Lsp2 links mTORC1 to TOP mRNA translation and lifespan in Drosophila.
Nature · 1 Oct 2026 · Journal Article
Loss of Lsp2 reduces TOP mRNA translation via 4E-BP, extending Drosophila lifespan independently of rapamycin, highlighting a new longevity pathway.
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Lsp2 links early-life diet to adult translation and lifespan in Drosophila.
Nature · 1 Oct 2026 · Journal Article
Larval-stage protein restriction reduces Lsp2 expression, decreases ribosomal proteins, and extends adult lifespan in Drosophila.
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Transgenerational inheritance of altered H3K27me3 in wild-type Caenorhabditis elegans.
EMBO Journal · 1 Oct 2026 · Journal Article
Transient alterations of H3K27me3 in C. elegans persist for many generations under selective pressure, affecting fertility in wild-type descendants.
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A protein language model links the E. coli pangenome functional landscape geometry to host proteostasis
bioRxiv · 30 Sept 2026 · Preprint
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Condensate-driven triglyceride reduction links α-synuclein to mitochondrial dysfunction.
EMBO Reports · 29 Sept 2026 · Journal Article
α-Synuclein reduces triacylglycerols and disrupts lipid droplets and mitochondria in aging Caenorhabditis elegans, linking lipid metabolism to toxicity.
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A multifunctional PKS-NRPS megasynthetase in nematodes produces divergent signaling molecules that control different developmental arrests.
Nature Communications · 29 Sept 2026 · Journal Article
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Dietary Restriction Impacts Peripheral Diurnal Rhythms Important for Longevity in Drosophila
bioRxiv · 28 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2023.01.04.522718
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Lifespan-extending downregulation of insulin signalling reduces germline mutation load
bioRxiv · 27 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.05.692572
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Innate immune stress pathway activation underlies heterochromatin dysfunction pathology
bioRxiv · 26 Sept 2026 · Preprint
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NLP-12/Cholecystokinin signaling stabilizes sensory dendritic structure and protects neuronal healthspan in Caenorhabditis elegans
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.05.709874
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DNA methylation variability provides a complementary epigenetic signature of aging heterogeneity: Findings from the Canadian Longitudinal Study on Aging and the Baltimore Longitudinal Study of Aging
bioRxiv · 25 Sept 2026 · Preprint
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