Microtubule and mitosis dynamics
Moving in bioRxiv, Nature Communications, eLife, Cell Reports, EMBO Reports, Nature, Nature Chemical Biology and EMBO Journal.
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Latest in Microtubule and mitosis dynamics
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Microtubule pushing forces are essential for preventing spindle stalling, enhancing robustness, and facilitating alignment alongside cortical pulling in diverse cell types.
- Open access
Physical confinement in 3D environments physically constrains budding yeast, drastically prolonging cell cycle progression without triggering regulatory or stress responses.
- Open access
Dysregulation of BUB gene family causes chromosomal instability linked to cancer progression, heterogeneity, metastasis, and therapy resistance.
- Open access
Oxidative DNA damage at centromeres promotes chromosome instability, with lesions leading to DNA breaks and aneuploidy in pre-tumorigenic cells.
- Open access
Reelin deficiency causes persistent disruptions in primary cilia orientation, localization, and length in principal neurons of the cerebral cortex, especially in laminated regions.
- Open access
- 1 cites
Inhibition of microhomology-mediated end joining reduces ecDNA levels and impairs cancer cell fitness by targeting TA-rich breakage sites.
- Open access
Metaphase plate width in eukaryotes scales with genome size following a power law with an exponent of approximately 1/3, driven by chromosome crowding.
- Open access
- 1 cites
Loss of rice ZEP1 protein causes asynapsis, multivalent formation, and chromosome fragmentation, disrupting meiotic genome integrity in rice.
- Open access
TRI-611 is the first clinical-stage molecular glue degrader targeting ALK fusion proteins, achieving tumor regression in ALK-positive NSCLC models.
GTSF-1 binds to an N-terminal domain of RRF-3 across nematodes, supporting 26G-RNA biogenesis and fertility in Caenorhabditis and related species.
- Open access
ACTL6A drives hypoxic adaptation and glycolysis in head and neck squamous cell carcinoma by activating AP-1 signaling and chromatin remodeling, with a critical role in tumor metabolism.
- Open access
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