Transient alterations of H3K27me3 in C. elegans persist for many generations under selective pressure, affecting fertility in wild-type descendants.
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Epigenetics and DNA Methylation
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A premalignant chromatin state linked to gastric cancer involves a pseudo-gastric subtype that exploits acid secretion to evade immune responses.
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Monocyte-lineage expansion is linked to transcriptomic individuality in genetically identical Dasypus novemcinctus quadruplets, with the most distinct individual showing increased monocytes.
- Open access
Sequential activation of TPRX1 and HERVL defines the stepwise progression toward human 8-cell-like cells in vitro.
- Open access
EZHIP evolved rapidly under positive selection in primates and exhibits dynamic expansions and losses across mammalian species, especially in placental mammals.
- Open access
- 2 cites
Partial preservation of cfDNA fragmentomic signals in methylation sequencing enables effective cancer detection models with the strongest performance from genome-wide integration.
- Open access
PUS7-mediated pseudouridylation of 7SK enhances human somatic cell reprogramming efficiency and chromatin accessibility.
- Open access
- 1 cites
A gene-centered framework reveals context-dependent shifts in DNA methylation biomarker candidates across multiple cancers.
- Open access
- 1 cites
High glucose and TNF-α induce extensive 3D chromatin reorganization in human macrophages, activating inflammatory genes and disrupting metabolic and cell cycle gene regulation.
A meta-analysis of 144 breast cancer samples reveals a common DNA methylation pattern across all subtypes, notably involving immune system and cell cycle deregulation.
- Open access
Loss of DNMT1 in cortical PV interneurons increases PV spiking but reduces inhibitory efficacy, leading to network desynchronization and depression- and anxiety-like behaviors in mice.
- Open access
Single-cell RNA sequencing reveals that epigenetic regulators form a hierarchy of interactions that influence development and genome stability in mouse embryos.
- Open access
Multi-omics and computational frameworks have significantly advanced understanding of epithelial-mesenchymal transition (EMT) by enabling comprehensive profiling of cellular states at unprecedented resolution.
Germline hypomethylation creates CpG-rich reservoirs in ape genomes, especially in dynamic regions like peri/centromeric satellites, influencing genome evolution.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
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