Protein Kinase Regulation and GTPase Signaling

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Physical confinement modulates the rate-limiting transition in the release of phosphate from actin filaments.
Science Advances · 23 Oct 2026 · Journal Article
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https://jclub.com.au/a/42905838
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Multiple allosteric sites allow for synergistic enhancement of GPCR signaling.
Science Advances · 23 Oct 2026 · Journal Article
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https://jclub.com.au/a/42905841
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Local Confinement within Plasma Membrane Nanodomains Promotes Constitutive Activity of GPCRs
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.17.706370
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BTK dynamics and function are differentially influenced by distinct covalent inhibitor warhead chemistries.
bioRxiv · 17 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.07.723540
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Mechanistic insight into the dual phosphorylation of ERK1 and ERK2 by MEK1
bioRxiv · 15 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.13.710243
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KRAS recognition by Src: Mechanistic insights from Molecular Dynamics Simulations
bioRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.17.712316
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Structural basis of context-dependent RORγt target gene activation on chromatin
bioRxiv · 11 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.10.642251
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PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12.
Nature Communications · 9 Oct 2026 · Journal Article
Roginolisib selectively inhibits PI3Kδ by stabilizing the C-terminal helix kα12, locking the enzyme in an inactive conformation.
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Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation and its reversal by selective PDE11A4-targeted small molecules in cells and brain
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.05.20.654583
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Integrated screens reveal that guanine nucleotide depletion, which is irreversible via targeting IMPDH2, inhibits pancreatic cancer and potentiates KRAS inhibition.
Gut · 7 Oct 2026 · Journal Article
Guanine nucleotide depletion via IMPDH2 inhibition suppresses pancreatic cancer and enhances KRAS inhibitor efficacy, with depletion being irreversible and independent of KRAS pathways.
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https://jclub.com.au/a/41494804
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Engineering synthetic proteins to toggle function in response to kinase signals.
Nature Reviews Molecular Cell Biology · 5 Oct 2026 · Journal Article
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https://jclub.com.au/a/42834136
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Regulation of polyphosphate homeostasis in S. cerevisiae by the Sky1 protein kinase
bioRxiv · 3 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753767
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KRAS inhibition drives adaptive surfaceome remodeling and reveals ALPP/ALPPL2 as a targetable vulnerability in pancreatic cancer
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.01.756025
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KRASG12C Inhibition Remodels the Non-Small Cell Lung Cancer Surfaceome to Uncover Targetable Vulnerabilities
bioRxiv · 2 Oct 2026 · Preprint
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Targeting Oncomucin-Driven Immunosuppression Improves the Efficacy of K-ras(G12D) Inhibition in Pancreatic Cancer.
Gastroenterology · 1 Oct 2026 · Journal Article
Targeting oncomucin-driven immune suppression enhances K-ras(G12D) inhibitor efficacy in pancreatic cancer by reducing tumor burden and immune checkpoints.
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https://jclub.com.au/a/42191046
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Lineage identity governs oncogene dependence in mouse NSCLC models of KRAS inhibitor resistance.
Nature Genetics · 1 Oct 2026 · Journal Article
Lineage transformation to squamous identity confers KRAS inhibitor resistance in mouse lung adenocarcinoma models.
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A double endocrine-disrupting effect of PFAS on intra- and extra-thyroid targets: inhibition of iodide uptake and interference with MCT8-mediated T3 transport in vitro.
Environmental pollution · 1 Oct 2026 · Journal Article
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Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation.
eLife · 30 Sept 2026 · Journal Article
Gβγ binds multiple sites on PLCβ3 to facilitate activation and reorient the enzyme for maximal PI(4,5)P2 hydrolysis in concert with Gα q.
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https://jclub.com.au/a/42814481
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Allele-Specific Mechanisms Guide Salvage Therapy to Overcome Daraxonrasib Resistance in Pancreatic Cancer.
Cancer Research · 30 Sept 2026 · Journal Article
KRASG12R pancreatic cancer cells develop resistance to daraxonrasib via EGFR/RASWT signaling, enabling effective trametinib-based therapy and extending patient survival to 40 months.
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PIP5K-Ras bistability triggers plasma membrane symmetry breaking to define cellular polarity and regulate migration.
Nature Communications · 30 Sept 2026 · Journal Article
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Structural and Energetic Determinants of Monobody Recognition of Oncogenic KRAS Variants
bioRxiv · 30 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.09.737552
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Greatwall kinase regulates acute myeloid leukaemia cell division through a non-canonical mechanism.
EMBO Reports · 30 Sept 2026 · Journal Article
Greatwall kinase regulates cytokinesis in AML cells through a novel pathway involving MARK3, independent of the ENSA-PP2A-B55 mechanism.
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https://jclub.com.au/a/42816598
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Multipath interaction network of annexin A2: multifaceted regulation and translational perspectives in neurological diseases.
Frontiers in Genetics · 28 Sept 2026 · Review
Annexin A2 operates within a multipath interaction network influencing neurological diseases, with many signaling outputs arising from membrane trafficking and receptor organization.
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https://jclub.com.au/a/42861417
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Structural basis of stepwise G protein activation by the viral chemokine receptor US28
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.10.692789
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PolyA/polyQ-mediated conformational rewiring regulates DNA engagement and drives aggregation in the neuronal transcription factor Ascl1
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.11.724289
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PCO371 intracellular agonism at the parathyroid hormone 1 receptor produces pan-activation of signalling partners
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.27.728112
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A bifunctional ARHGEF17-AS1 locus encodes MSEP, a protein that supports mitotic spindle organization.
Cell Reports · 24 Sept 2026 · Journal Article
A novel ∼54-kDa protein, MSEP, encoded by the ARHGEF17-AS1 locus, is essential for mitotic spindle organization and localizes to spindle poles.
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https://jclub.com.au/a/42789387
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Targeting RAS for Pancreatic Cancer Interception.
Cancer Discovery · 22 Sept 2026 · Journal Article
Targeting RAS mutations offers promising strategies for intercepting pancreatic cancer at its precancerous stage.
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TCF25 emerges as a cytoplasmic regulator of GPRASP2 stability
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.714440
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Uncoupling of the allosteric signalling network in the β(1)-adrenergic receptor by a negative allosteric modulator.
Nature Communications · 18 Sept 2026 · Journal Article
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https://jclub.com.au/a/42897158
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