DNA-based GNOS-PV01 and peptide-based NeoVax vaccines show promise for glioblastoma patients, with GNOS-PV01 effective against the challenging MGMT-unmethylated subtype.
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Glioma Diagnosis and Treatment
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Spatial transcriptomics reveals distinct tumor cell states and multicellular niches along the core-edge axis in glioblastoma.
- Open access
- 4 cites
Neural recordings can accurately track glioma progression in vivo, with elevated gamma-band activity consistently linked to tumor growth in mouse models.
- Open access
D2C7-ATC therapy is linked to prolonged survival in a subset of patients with IDHwt recurrent glioblastoma, with a median overall survival of 17.38 months in certain cases.
Fungal diversity is significantly lower in the gut of glioblastoma patients compared to healthy controls, with a p-value less than 0.001.
- Open access
Reactive astrocyte-like tumor cells with mesenchymal and injury-response signatures are enriched after radiotherapy and persist in recurrent glioblastoma in a mouse model.
- Open access
HERO reduces and refines whole-brain atlas-mapped cellular datasets by enabling hierarchical analysis, improving data clarity and reproducibility across neuroscience studies.
- Open access
CAR-engineered microglia selectively eliminate GBM cells through phagocytosis in organoid models, showing increased phagocytic activity and tumor transcript internalization.
- Open access
Levetiracetam extends survival in children with diffuse midline glioma by targeting GABAergic synapses, but not in other glioma subtypes.
- Open access
Wild type bone marrow-derived microglia-like cells prevent strain-dependent thalamic calcification in Csf1r mutant mice.
- Open access
- 7 cites
Inhibiting autophagy with ATG7 silencing nanoparticles enhances radiotherapy effectiveness in high-grade mutant IDH1 gliomas, leading to tumor regression and long-term survival.
- Open access
NFIs act as conserved global temporal regulators of radial glial progenitor development, with mutations causing bidirectional impairments linked to human neocortical malformations.
Aptamer-guided delivery of miR-126 significantly reduces glioblastoma stem-like cell invasion and tumor progression in mouse models.
- Open access
DLL3 is essential for glioma cell viability and proliferation, with its depletion suppressing cell cycle pathways and inducing broad transcriptional reprogramming in glioma.
- Open access
Spatial organization of IDH-mutant gliomas shifts from anatomy-driven in low-grade tumors to hypoxia-driven in high-grade tumors, revealing two distinct axes of tumor structure.
- Open access
- 1 cites
Mapping 202 MRI-localized biopsies from 58 glioma patients reveals three key tissue states and 14 MRI habitats linked to tumor biology and progression.
- Open access
- 7 cites
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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- Alzheimer's disease research and treatments3
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