TCR origin and antigen recognition shape peripheral Treg cell differentiation, with TCRs from Treg cells more effectively inducing tolerance across diverse antigens.
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T-cell and B-cell Immunology
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Epithelial NF-κB activity promotes a protective Treg cell response that is crucial for resolving intestinal inflammation in colitis.
- Open access
Rapid peak cilta-cel expansion is linked to increased risk of delayed neurotoxicity in patients with relapsed/refractory multiple myeloma.
γδ T cells activated by a BiTE can target small cell lung cancer independently of MHC-I expression, overcoming limitations of CD8+ T cell responses.
Genetic deletion of Zbtb44 causes spontaneous colitis and rectal prolapse in mice, with Zbtb44 -/- T cells showing increased IFN-γ expression.
BCR signaling strength determines the likelihood of VH gene replacement in peripheral B cells, with weaker signals increasing VHR frequency.
Geranylgeranyltransferase type II (GGTase II) is essential for B-cell activation, proliferation, and plasma cell survival, with its inhibition reducing autoimmune disease activity in mice.
ITK deficiency nearly completely prevents autoimmune pulmonary hemorrhage by enhancing regulatory T cell function in a mouse model.
- Open access
Cysteine reactivity profiling uncovers metabolic rewiring that impairs T cell function, with significant changes linked to stress pathways and ATP depletion in dysfunctional human T cells.
- Open access
- 1 cites
MARCH2 and MARCH3 redundantly target FcγRI for K27-linked polyubiquitination and lysosomal degradation, limiting inflammatory responses in mice.
CytoVI accurately models antibody-based single-cell data, revealing proteins linked to immunoglobulin class-switching and disease-associated T cell states in B cell non-Hodgkin lymphoma.
- Open access
Alterations in glycolysis, mitochondrial function, and mTOR signaling in lymphocytes are linked to the development of T-cell-mediated autoimmunity in diseases like MS, RA, and T1D.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3