Neurological diseases and metabolism

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"Plasma Membrane Calcium ATPase Downregulation in Dopaminergic Neurons Induces Presynaptic Dysfunction and Neuronal Vulnerability In Vivo and In Vitro"
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721667
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Non-canonical cytochrome P450 enzymes expand the diversity of bacterial hemoproteins.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42342846
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Discovery of noncanonical cytochrome P450 enzymes in nature.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
Twenty noncanonical cytochrome P450 families lacking a conserved cysteine ligand are identified in diverse microbial genomes, including the first native selenocysteine-ligated CYP.
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https://jclub.com.au/a/42332020
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Case Report: McLeod syndrome caused by a nonsense variant c.484C > T (p.Gln162Ter) in the XK gene in a Chinese Han family.
Frontiers in Genetics · 1 Oct 2026 · Case Reports
A novel XK c.484C > T (p.Gln162Ter) variant is linked to McLeod syndrome in a Chinese Han family, expanding the genetic and ethnic spectrum of the disease.
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https://jclub.com.au/a/42889322
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Microbiota-derived pantothenic acid rapidly restores colonic mucus barrier after antibiotic-induced dysbiosis
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.25.754384
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Coenzyme A activates TLR4 and enhances alternative macrophage activation in line with MyD88 agonism.
EMBO Reports · 18 Sept 2026 · Journal Article
Exogenous CoA acts as a weak TLR4 agonist that enhances IL-4 driven macrophage activation via MyD88 in vitro and in vivo.
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https://jclub.com.au/a/42760443
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Sex-stratified analysis of the potential association between PGLYRP2 rs892145 variant and Parkinson's disease across diverse ancestral populations
medRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.23.25331993
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Gut commensal Bacteroides-derived pantothenic acid alleviates metabolic syndrome.
Cell Host & Microbe · 9 Sept 2026 · Journal Article
Gut-derived pantothenic acid from Bacteroides fragilis improves metabolic syndrome by restoring gut barrier function and reducing inflammation.
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https://jclub.com.au/a/42385714
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Growth-coupled microbial biosynthesis of the animal pigment xanthommatin.
Nature Biotechnology · 1 Sept 2026 · Journal Article
Growth-coupled biosynthesis in Pseudomonas putida achieves gram-scale xanthommatin production by linking pigment synthesis to C1 metabolism, reaching significant bioproduction levels.
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https://jclub.com.au/a/41184490
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