Modular architecture of phage defense systems enables the discovery of three new systems in Pseudomonas aeruginosa.
Cell Host & Microbe
Cell Press · Microbiology & Mycology · ISSN 1931-3128, 1934-6069
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Modular architecture of phage defense systems enables the discovery of three new systems in Pseudomonas aeruginosa.
Akkermansia muciniphila suppresses macrophage efferocytosis via TLR2/NF-κB, activating immune pathways that enhance anti-PD-1 therapy in MSS colorectal cancer.
Gemella morbillorum is enriched in colorectal cancer tissues and promotes tumorigenesis by disrupting the intestinal barrier and causing DNA damage through invasion-dependent lipid peroxidation.
Akkermansia muciniphila supplementation reduces endometritis in mice by increasing tyrosol levels and activating the PI3K/AKT pathway.
An enzyme-responsive nanoplatform enhances microbial indole metabolism and suppresses kynurenine pathway to boost cancer immunotherapy efficacy.
A comprehensive proteome of chromatin domains in P. falciparum reveals 214 proteins, including novel components and a Bub1-like kinase, expanding understanding of parasite epigenetics.
Corynebacterium glucuronolyticum-like bacteria promote calcium oxalate kidney stone formation by degrading hippuric acid and facilitating crystal aggregation.
Mutant KRAS in colorectal tumors favors Bacteroides acidifaciens, which signals back to reinforce RAS-MAPK signaling.
Dual activation of bacterial DRT2 reverse transcriptase by phage-encoded SSB and elevated dGTP triggers membrane-targeting Neo protein production.
FadA effector from Legionella pneumophila modifies host mRNA with NADPH-oxidase activity, increasing oxo 8 G modifications and promoting bacterial persistence in vivo.
Plant virus-derived siRNAs establish an AGO1-dependent immune zone in uninfected short-range cells, with viral suppressors of RNA silencing affecting this pre-immunization.
Legionella pneumophila modifies host mRNA to suppress inflammation using a newly identified bacterial effector.
Adaptive mutations in Bacteroides thetaiotaomicron rapidly spread between co-housed mice, overcoming colonization resistance and enabling engraftment of specific lineages.
Intestinal Collinsella aerofaciens and its metabolite indole-3-acetamide are significantly reduced in women with PCOS, and IAM activates HIF-2α signaling to improve the condition.
Streptococcus anginosus drives gastric cancer progression and immune evasion via the saSNF2-ZDHHC11 axis, promoting tumor growth and limiting immune infiltration.
Bacteroides acidifaciens enriched by KRAS mutation promotes colorectal tumorigenesis in KRAS-mutant models.
A gut microbial metabolite reprograms adipose ceramide metabolism, linking microbial signals to ovarian function in polycystic ovary syndrome.
VsiRNAs drive plant antiviral immunity through reiterated 3-4 cell immunization events, even when intracellular RNAi is suppressed by TuYV infection.
C. glucuronolyticum-like bacteria promote calcium oxalate crystallization by degrading hippuric acid, with potential to be targeted for kidney stone prevention.
Microbial bile acid metabolism is strongly linked to the pathogenesis of intestinal diseases, including inflammatory bowel disease, enteric infections, and colorectal cancer.
Turning bacterial surfaces into oral vaccine couriers and microbial metabolism into controllable reactors demonstrates how microbiome therapeutics can be transformed into precision platforms for cancer immunotherapy.
Candidozyma auris exploits hair follicles and chitin exposure to induce IFNγ responses that promote its persistence on skin.
Prophage-encoded AppA provides a novel anti-phage defense mechanism that suppresses phage expansion in the mammalian gut, influencing disease outcomes.
Increasing MIPS expression in wheat and maize confers up to 88% reduction in DON accumulation and rescues 43% of yield loss in Fusarium disease.
A bacterial exopolysaccharide containing phosphocholine from Clostridium immunis prevents and treats obesity in mice by regulating IL-22 levels.
Dietary pectin induces a microbiota-dependent high-IgA phenotype in gnotobiotic mice colonized with Bacteroides uniformis, mediated by bacterial surface remodeling.
Advances in vaccines, antibodies, and antivirals offer hope for combating hantavirus infections, which currently lack approved medical countermeasures.
The rice circadian clock component Nhd1 synchronizes rhizosphere microbial activity with plant nitrogen demand, enhancing nitrogen use efficiency by up to 40%.
Fibroblasts at the granuloma periphery, regulated by LTA4H, limit mycobacterial spread and influence tuberculosis severity.
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Topics moving, week to 22 Oct 2026
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