Chromatin Remodeling and Cancer
Moving in bioRxiv, Nature Communications, Cancer Research, Cell Reports, Nature Chemical Biology, Cancer Discovery, Cell and eLife.
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Latest in Chromatin Remodeling and Cancer
Newest first · last 60 days
Recurrent genomic driver alterations are identified in 97% of primary prostate tumors, revealing four distinct oncotypes with varying clinical outcomes.
- Open access
AmpliconSuite accurately predicts ecDNA and amplification modes in 72 models and reveals ecDNA-mediated oncogene co-amplification in 6,506 pan-cancer samples.
- Open access
Inhibition of CDK12 induces BRCAness and apoptosis in neuroblastoma cells, with OKI-1546 reducing tumor growth and extending survival in vivo.
- Open access
High glucose and TNF-α induce extensive 3D chromatin reorganization in human macrophages, activating inflammatory genes and disrupting metabolic and cell cycle gene regulation.
SPOP-mutant prostate cancer exhibits Wnt pathway dysregulation and diverse transcriptional signatures across racial groups, with 40 tumors analyzed for genomic and transcriptomic features.
- Open access
A/B chromatin compartments in mouse embryonic stem cells show a sudden increase in strength during S-phase, indicating unexpected plasticity across interphase.
- Open access
Kidzoi, a kidney cell-type-specific S2F model, improves regulatory variant effect prediction by 10-23% over existing models.
- Open access
High-risk rhabdomyosarcomas exhibit a shared convergent cell state with neural features, regardless of FOXO1 fusion status.
- Open access
ALKBH5 in cancer-associated fibroblasts promotes pancreatic cancer metastasis through an epitranscriptomic signaling axis.
- Open access
SAGA and ATAC co-activator complexes use different strategies, with distinct interactions and chromatin-reading capabilities, to regulate gene transcription in cancer cells.
- Open access
Monovalent degraders can recruit two E3 ligases, DCAF16 and FBXO22, to degrade SMARCA2/4, with ligase dependency being chemically and genetically tunable.
- Open access
- 2 cites
ACTL6A drives hypoxic adaptation and glycolysis in head and neck squamous cell carcinoma by activating AP-1 signaling and chromatin remodeling, with a critical role in tumor metabolism.
- Open access
MutationProjector, a pre-trained genomic model, predicts therapeutic resistance and sensitivity across multiple cancer types with performance matching or exceeding state-of-the-art methods.
- Open access
Expanded DNA methylation-based sarcoma classifier achieves 98% accuracy across 116 tumor sub-classes, significantly enhancing diagnostic precision for mesenchymal tumors.
- Open access
- 3 cites
Meiotic cohesin complexes, including REC8 and STAG3, are expressed in embryonic stem cells and influence chromatin architecture and gene regulation.
- Open access
SMARCB1-deficient tumors are highly sensitive to H3K27 demethylase inhibitors, with GSK-J4 suppressing tumor growth in patient-derived models.
Ryder improves epigenomic data normalization by effectively reducing technical noise across diverse assays, enabling clearer detection of biological signals.
- Open access
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Topics moving, week to 23 Oct 2026
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