Amino Acid Enzymes and Metabolism

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SIK3 controls synaptic localization of NMDA receptors by phosphorylating GluN1.
Nature Neuroscience · 21 Oct 2026 · Journal Article
SIK3 phosphorylation of GluN1 is essential for recruiting NMDARs to synapses, with deletion reducing synaptic GluN1 levels by approximately 60% in neurons.
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Cold activates a BH2 metabolic network promoting longevity and proteostasis.
Nature · 21 Oct 2026 · Journal Article
Cold activates a BH2 metabolic network that promotes longevity and proteostasis in Caenorhabditis elegans, with increased BH2 synthesis in muscle being sufficient for these effects.
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Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity.
eLife · 12 Oct 2026 · Journal Article
Human glutamine synthetase forms product-stabilized filaments that reduce catalytic specificity at physiological glutamine levels.
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A double endocrine-disrupting effect of PFAS on intra- and extra-thyroid targets: inhibition of iodide uptake and interference with MCT8-mediated T3 transport in vitro.
Environmental pollution · 1 Oct 2026 · Journal Article
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Multiomic proximity labeling in vivo by D-amino-acid-activated peroxidase reaction.
Nature Chemical Biology · 30 Sept 2026 · Journal Article
PRADA enables in vivo proximity labeling of proteins and RNAs across multiple organisms, revealing RNA folding as a key regulator of mitochondrial gene expression.
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MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency.
Cell Reports · 29 Sept 2026 · Journal Article
Loss of MTAP in pancreatic ductal adenocarcinoma (PDAC) increases BCAT1 expression by DNA demethylation, leading to a 2.5-fold BCAA dependency that promotes tumor progression.
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D-serine suppresses one-carbon metabolism by competing with mitochondrial L-serine transport
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.09.03.610855
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Pulsed-SILAC in single mouse embryos reveals early embryonic protein synthesis dynamics and phosphosite regulation
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.754052
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Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.04.663231
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Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.18.618978
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Activity-guided discovery of antibiotic-transforming bacteria from environmental microbiomes using D-amino acid-assisted fluorescence-activated cell sorting.
Environmental pollution · 15 Sept 2026 · Journal Article
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N-Acetylaspartate Synthesis as a Thermodynamic Relief Mechanism for Mitochondrial Aspartate Aminotransferase
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.29.735215
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Astrocytic PI3Kα controls synaptic plasticity and cognitive function via serine metabolism.
Nature Communications · 4 Sept 2026 · Journal Article
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https://jclub.com.au/a/42834036
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Integrated transcriptomics approach identifies the upregulated SLC7A5, and associated pathways across different thyroid cancer cell types.
Frontiers in Genetics · 3 Sept 2026 · Journal Article
Upregulated SLC7A5 across thyroid cancer cell types highlights potential therapeutic targets, with significant expression in KTC-1 cells and interactions with key genes.
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Keeping time with protein turnover.
Nature Cell Biology · 1 Sept 2026 · Journal Article
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