Cancer, Lipids, and Metabolism

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Latest in Cancer, Lipids, and Metabolism

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De novo lipogenesis controls antigen presentation and metastatic immune escape in triple-negative breast cancer.
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.21.726063
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Thermodynamic Quality Control Reshapes Spatially Resolved Metabolic Flux Predictions in Prostate Cancer
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.25.734531
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Lean, mean, breast cancer-fighting machine.
Nature Reviews Cancer · 16 Oct 2026 · Journal Article
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Interventions to manage intolerance among patients prescribed statins for primary prevention of cardiovascular diseases: A systematic review and meta-analysis
medRxiv · 12 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.23.26346865
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Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stress.
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.06.727699
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Targeting p300 Reverses Acidic Microenvironment-Induced PARP Inhibitor Resistance.
Cancer Research · 2 Oct 2026 · Journal Article
Acidic tumor microenvironment induces PARPi resistance in epithelial ovarian cancer through p300-dependent mechanisms.
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PDE5A Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking through a Noncanonical cGMP-Dependent Pathway.
Cancer Research · 2 Oct 2026 · Journal Article
PDE5A inhibitors, including sildenafil, induce lysosomal cholesterol accumulation and reduce metastasis in cancer models by disrupting NPC1-mediated cholesterol trafficking.
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https://jclub.com.au/a/42446922
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Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas.
Cancer Discovery · 1 Oct 2026 · Journal Article
Diets high in oleic acid (MUFA) markedly enhance pancreatic tumorigenesis, while polyunsaturated fatty acids (PUFA) suppress tumor progression in a mouse model.
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A signal to boost cholesterol.
Nature Cell Biology · 1 Oct 2026 · Journal Article
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Treatment-Resilient Lipid Remodeling Defines Temozolomide Resistance and Failure of Simvastatin Sensitization in Glioblastoma
bioRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.19.712341
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ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesisand fatty acid oxidation in colorectal cancer
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753323
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β3-Integrin controls pericyte metabolic states and shapes tumour-stromal metabolic crosstalk in breast cancer
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.751368
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Population-scale plasma proteomics reveals pre-diagnostic biomarkers and shared pathways of cancer risk across 25 cancers
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363676
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Suppression of de novo lipogenesis and dietary PUFA supplementation inhibit prostate cancer progression
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.25.714193
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Zonated cholesterol sensing by SIRT2 drives MASLD-HCC.
Cell Metabolism · 17 Sept 2026 · Journal Article
Zonated cholesterol sensing by SIRT2 initiates MASLD-related hepatocellular carcinoma, with SIRT2 overexpression in zone 1 causing tumors in mice and humans.
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Targeting valine metabolism and ferroptosis to overcome chemoresistance in PDAC.
Nature Cancer · 14 Sept 2026 · Journal Article
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Structural basis for rosuvastatin-induced activation of skeletal muscle ryanodine receptor 1.
Nature Communications · 3 Sept 2026 · Journal Article
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Comment on "Serum procalcitonin: A novel tumor biomarker for … fibrolamellar hepatocellular carcinoma".
Journal of hepatology · 1 Sept 2026 · Letter
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Targeting PID1 generates oxysterols to switch macrophage cell fates for improved antitumor immunity.
Nature Cancer · 1 Sept 2026 · Journal Article
Targeting PID1 in tumor-associated macrophages produces oxysterols that reprogram macrophages toward an antitumor phenotype, enhancing immune responses in multiple cancers.
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Steatosis fuels replacement liver metastases in colorectal cancer.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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