Erythrocyte Function and Pathophysiology

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Yoda molecules agonize PIEZO2
bioRxiv · 13 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.08.723777
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Paralogous mutations in the Plasmodium falciparum surface anion channel associate with reduced protection due to sickle hemoglobin.
Cell Reports · 6 Oct 2026 · Journal Article
Mutations in Plasmodium falciparum's CLAG3 paralogs are linked to a 50% reduction in sickle hemoglobin's protective effect against malaria.
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Dissipation of lysosome pH impairs formation and collapses existing LPS-induced lysosome tubules in macrophages
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.25.677195
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A novel Band 3-BLVR axis in red blood cells.
Blood · 17 Sept 2026 · Editorial
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The red blood cell proteome and interactome identify a Band 3-BLVRB axis regulating hypoxic metabolic adaptation.
Blood · 17 Sept 2026 · Journal Article
The Band 3-BLVRB interaction acts as an oxygen-sensitive switch regulating red blood cell metabolism, with hypoxia causing dissociation and metabolic remodeling.
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Osmo-hydraulic volume regulation ensures robust endothelial-to-haematopoietic transition
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.09.711986
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Treatment of Anemia in Chronic Kidney Disease Enters the Era of Personalization.
Annals of Internal Medicine · 15 Sept 2026 · Journal Article
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Microbial adhesion promotes Piezo1 activation to initiate innate immunity.
Nature Immunology · 9 Sept 2026 · Journal Article
Microbial adhesion activates Piezo1 to initiate innate immunity, triggering neutrophil recruitment before pattern recognition receptor engagement.
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GLUL facilitates thrombocytopoiesis by restricting ammonia accumulation during megakaryocyte maturation.
Blood · 3 Sept 2026 · Journal Article
GLUL promotes thrombocytopoiesis by preventing ammonia buildup during megakaryocyte polyploidization, with deficiency impairing platelet production in mice.
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Mechanism of the M. tuberculosis DprE1-DprE2 epimerase complex and inhibition by anti-tubercular drugs.
Nature Chemical Biology · 2 Sept 2026 · Journal Article
Cryo-EM structures reveal how the M. tuberculosis DprE1-DprE2 complex interacts with anti-tubercular drugs, providing insights into their mechanisms of inhibition.
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Glycolytic suppression of cell adhesion promotes thyroid morphogenesis in response to nutrition.
EMBO Reports · 1 Sept 2026 · Journal Article
Glycolytic activity suppresses cell adhesion, promoting thyroid morphogenesis in Xenopus tadpoles, with a 50% increase in follicle formation under glycolytic conditions.
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PIEZO1 senses the mechanics of liver regeneration.
Nature reviews. Gastroenterology & hepatology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42463526
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Biomechanical regulation of Ca2+ dynamics during muscle stem cell activation
bioRxiv · 28 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.19.726396
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Expanding the genetic landscape of SLC4A1-linked hereditary spherocytosis: discovery of a novel TM9 variant using high-resolution genomic profiling analysis.
Frontiers in Genetics · 27 Aug 2026 · Journal Article
Seven SLC4A1 variants, including a novel p.Phe702Ser in TM9, were identified in Indian hereditary spherocytosis patients, expanding the mutation spectrum.
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