Barrier Structure and Function Studies
Moving in bioRxiv, The lancet. Gastroenterology & hepatology, Applied and environmental microbiology, Blood, Cell Reports, Communications Biology, Gastroenterology and Gut.
- Moved, week to 23 Oct 2026
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- Papers in 60 days
- 28
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Latest in Barrier Structure and Function Studies
Newest first · last 60 days
Early infiltration of ischemia-conditioned Tregs at day 5 post-MCAO reduces BBB damage by suppressing neutrophil extracellular traps in ischemic stroke.
- Open access
Up-regulation of CLDN2 in human and mouse pancreatitis models limits disease severity by promoting pancreatic ductal fluid transport.
- Open access
Restoring gut barrier function with targeted therapies may transform treatment of disorders of gut-brain interaction.
Cochlin, an extracellular matrix protein, enhances brain immune defense by reducing bacterial load, with levels increasing during infection in zebrafish, mice, and humans.
- Open access
Elevated blood-brain barrier permeability in sickle cell disease correlates with microstructural brain injury, with 79 plasma proteins linked to systemic pathways influencing BBB disruption.
PAK4 is essential for vertex remodeling, maintaining epithelial integrity and barrier function, with its inhibition increasing vertices by 50% and causing junctional defects.
- Open access
- 1 cites
Trogocytosis-related CLDN18.2 impairs CD8(+) T cell cytotoxicity and promotes pancreatic cancer progression by degrading β-catenin and inducing immune senescence.
- 2 cites
Molecular regulators and cell interactions make the blood-brain barrier a dynamic, highly selective interface crucial for CNS health and disease.
Targeting claudins offers a promising new approach, with zolbetuximab becoming the first FDA-approved CLDN-18.2-targeted antibody for gastric cancer treatment.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3