Immunodeficiency and Autoimmune Disorders

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A Novel Aspergillus Galactomannan Chemiluminescence Immunoassay: Evaluation for Diagnosis of Invasive Pulmonary Aspergillosis in a Multicenter Controlled Study.
Medical Mycology · 21 Oct 2026 · Journal Article
GM-CLIA demonstrates high sensitivity (93.97% in serum, 93.58% in BALF) and specificity (97.46% in serum, 95.76% in BALF) for diagnosing invasive aspergillosis in serum and BALF samples.
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A systems perspective on monoallelic inborn errors of immunity.
Nature Genetics · 20 Oct 2026 · Review
Monoallelic variants in inborn errors of immunity often perturb signaling pathways rather than abolish gene function, highlighting complex system-level influences on disease expression.
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Dysfunctional effector programming in Foxp3-ΔE2 Tregs promotes enhanced CD8+ T cell responses
bioRxiv · 9 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.20.719728
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Can Large Language Models Diagnose Primary Immunodeficiency from Patient-Described Symptoms?
medRxiv · 4 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.26.26353818
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ABTB1, as an E3 ubiquitin ligase, suppresses Th17 cell differentiation and mitigates autoimmune inflammation by promoting STAT3 ubiquitination and degradation.
Cellular & molecular immunology · 1 Oct 2026 · Journal Article
ABTB1 functions as an E3 ubiquitin ligase that promotes STAT3 degradation, suppressing Th17 cell differentiation and reducing autoimmune inflammation.
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Obexelimab and the Promise of Nondepleting B-Cell Therapy in IgG4-Related Disease.
New England Journal of Medicine · 1 Oct 2026 · Editorial
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Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity.
Nature · 30 Sept 2026 · Journal Article
Loss of histone readers MLLT1 and MLLT3 eliminates all AID-dependent mutagenic activity, highlighting their essential role in locus-specific antibody diversification.
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Respiratory Syncytial Virus infections in immunosuppressed adults <65 years old: a comparative analysis with Influenza and SARS-CoV2
medRxiv · 23 Sept 2026 · Preprint
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DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity.
eLife · 18 Sept 2026 · Journal Article
DGKα and ζ deficiency in Tregs causes destabilization and conversion to pathogenic exTreg-Tfh2 cells, triggering IgG1/IgE autoantibody-driven multiorgan autoimmunity.
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Humoral correlate of vaccine-mediated protection from tuberculosis identified in humans and non-human primates
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.05.627012
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Gastroenterology · 1 Sept 2026 · Letter
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Effectiveness of Risankizumab After Ustekinumab Failure in Crohn's Disease: A Multicenter Retrospective Cohort Study.
Gastroenterology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42107795
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Primary Immunodeficiencies Masquerading as Inflammatory Bowel Diseases.
Gastroenterology · 1 Sept 2026 · Journal Article
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Bridging Genetics and Bedside Decisions in Inflammatory Bowel Disease: Utility Metrics for Susceptibility Polygenic Scores.
Gastroenterology · 1 Sept 2026 · Letter
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Ibrutinib for early-stage CLL: genetic risk factors and treatment outcome in the GCLLSG CLL12 trial.
Blood · 27 Aug 2026 · Clinical Trial, Phase III
Ibrutinib improves event-free survival in early-stage CLL patients with certain genetic mutations but offers no overall survival benefit across all subgroups.
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Multi-kingdom signatures of the gut microbiome in Lynch syndrome: a prospective model for colorectal cancer evolution.
Gut · 25 Aug 2026 · Letter
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