Targeting ZIP12 with the monoclonal antibody APL-9796 reduces pulmonary hypertension symptoms in rodent models and shows promise as a therapy for PAH.
Trace Elements in Health
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Yersinopine is a primary zinc acquisition system in Yersinia pseudotuberculosis, essential for growth under zinc-limited conditions, unlike in Yersinia pestis where it is inactive.
- Open access
Co-exposure to lead and hypertension in mice significantly worsens anxiety- and depression-like behaviors, with effects linked to cGAS phase separation and astrocyte senescence.
Serum lithium, nickel, and manganese concentrations, along with LNCM mixture exposure, are positively associated with increased CKD risk in Chinese older adults, with lithium contributing most strongly.
Prenatal arsenic exposure is linked to increased offspring blood pressure through disruptions in carnitine metabolism, with stronger effects from early to mid-pregnancy exposure.
Intracellular Zn 2+ directly inhibits mouse Slo3 potassium channels in a dose-dependent manner at micromolar concentrations, with slow dissociation, during sperm capacitation.
- Open access
A 28-year-old Chinese woman was diagnosed with both Wilson disease and tuberous sclerosis complex, marking the first reported case of their co-occurrence.
- Open access
Copper ion-induced MYH9 polymerization triggers cuproptosis, with 50% of drug-resistant tumor cells showing elevated copper levels facilitating this process.
- Open access
Copper exposure significantly impairs olfactory signal transduction and reduces feeding-related behavior in zebrafish, with up to a 56% decrease in olfactory function.
Zn-Se co-application in wheat reduces grain Se levels by 50% but still meets human nutritional requirements, revealing complex multi-scale antagonism mechanisms.
- Open access
A leucine-rich repeat receptor kinase called CERI is essential for systemic nitrogen-demand signalling in plants, with CERI loss impairing this process in Arabidopsis.
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Topics moving, week to 23 Oct 2026
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