Machine learning and new technologies are expected to accelerate diagnostics and therapeutics development to combat antimicrobial resistance.
Science Translational Medicine
American Association for the Advancement of Science · General Science & Medicine · ISSN 1946-6234
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VG-3927, an oral TREM2 agonist, shows high CNS penetration and reduces CSF sTREM2 in humans, supporting further development for Alzheimer's disease.
Wider access to clean water and sanitation is essential in the fight against bacterial diseases.
RPT04402 molecular glue restores PP2A trimer formation and induces tumor regression in high-grade uterine cancer models with PPP2R1A mutations.
Metabolomic age acceleration predicts increased risk of chronic diseases and mortality across the human lifespan in 18,476 individuals.
Orthogonal Fc engineering enables multiplexed mRNA delivery of bispecific antibodies that neutralize diverse SARS-CoV-2 variants in mice.
Elevated quinolinic acid levels are linked to worsened kidney injury and fibrosis in models of AKI-to-CKD transition.
AI-driven methods now facilitate the exploration of vast chemical and sequence spaces, enabling the design of synthesizable antibiotics with diverse mechanisms.
Rifampicin-resistant TB requires urgent integration into the global antimicrobial resistance response through diagnostics, surveillance, and treatment optimization.
A 3D-printed tolerogenic artificial lymph node (tol-aLN) induces durable antigen-specific tolerance and suppresses disease in advanced multiple sclerosis models.
Human microglia clear intraneuronal α-synuclein aggregates via GPNMB-mediated trogocytosis, with GPNMB up-regulation linked to disease-associated microglia in Parkinson's disease.
Cancer reprograms peripheral nerves to promote immune evasion, and targeting this process can restore responses to immunotherapy.
Split-intein and myotropic AAV vectors enable full-length dysferlin expression and functional recovery in an LGMDR2 mouse model, surpassing previous strategies.
JAK2V617F mutation causes erythrocyte stiffening that impairs clot contraction and promotes unstable thrombi in myeloproliferative neoplasms.
Preterm placental inflammation shows a distinct immune profile with cytotoxic T cells, activated macrophages, and NK cells, unlike the immune niches seen at term.
Early-life microbiota induce epithelial S100A9 expression, which is essential for neonatal immunity, as shown by increased infection susceptibility in knockout mice.
M5493, a novel drug candidate targeting a parasite TRP channel, shows potent activity against multiple stages of Schistosoma mansoni at doses as low as 5 mg/kg in mice.
MRSA persists in the kidney's hyperosmotic inner medulla by evading immune detection and utilizing tissue polyamines, with 1.8-fold increased bacterial survival observed in this niche.
DAPS, a wrist-worn accelerometer digital biomarker, can reduce clinical trial sample sizes for upper-limb motor recovery by over 60%.
A single 4-hour topical therapy eradicates all mites and eggs in a human-relevant porcine model of severe scabies, outperforming standard oral ivermectin.
Cranial bone marrow-derived monocytes promote neuroinflammation and neurological deficits in chronic traumatic brain injury, especially in older patients.
Combining FAK inhibitor and RAF/MEK clamp avutometinib with KRAS G12C inhibitor enhances tumor suppression in NSCLC models, surpassing single or double therapies.
Prime editing achieves up to 70% correction of GATA2 variants in human CD34+ hematopoietic stem cells, increasing functional GATA2 alleles from 50 to 77%.
SCRMP-mediated SUMOylation of CSNK2B enhances DNA repair and is linked to platinum resistance in small cell lung cancer.
FDA-approved drugs fosaprepitant dimeglumine and ciclesonide show uterus-selective tocolytic activity, inhibiting contractions without affecting fetal mouse ductus arteriosus tone.
Kamuvudine-9 (K-9) prevents neurological deficits and reverses paralysis and vision loss in a mouse model of MS, with myelin and axonal preservation.
Higher CSF CXCL1 levels before pCSI are linked to worse treatment response and increased LM growth in patients with leptomeningeal metastasis.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3