Most human genes produce multiple protein isoforms through alternative splicing, with recent evidence showing these isoforms are widespread, biochemically distinct, and linked to disease.
- 1 cited this week
RNA Research and Splicing
Moving in Trends in Genetics.
- Moved, week to 23 Oct 2026
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- Papers in 60 days
- 125
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RNAcomp2D enables simultaneous comparison of multiple RNA secondary structure prediction methods through a unified web interface.
- Open access
Corrected splicing metrics reveal distinct NMD-sensitive and NMD-evading transcript classes with improved accuracy from short-read RNA-seq data.
- Open access
Early life environment has a lasting impact on alternative splicing in Acyrthosiphon pisum, with effects comparable in magnitude to morph-specific differences.
- Open access
Reduced distance between pre-mRNA 3' cleavage and transcription termination correlates with increased gene expression in colorectal cancer cells.
- Open access
Bicon-seq identifies Gas5 as a highly conserved, essential lncRNA associated with NUP98::KDM5A onco-condensates in AML cells.
- Open access
Nuclear-BRITE enables fast, single-molecule live-cell imaging of nuclear RNAs with reduced background noise, surpassing previous MS2 system limitations.
HOTAIR adopts a multidomain architecture with conserved regions across primates, showing structural covariation in specific domains relevant to gene regulation in cancer.
- Open access
Incorporating desolvation effects into coarse-grained models reveals that desolvation energetics significantly influence the thermodynamics and kinetics of biomolecular liquid-liquid phase separation.
- Open access
Enhancer-AAVs achieve over 95% cell type specificity in targeting oligodendrocytes and astrocytes across species, enabling detailed glial cell studies.
- Open access
- 25 cites
Cytoplasmic TDP-43 gain-of-function causes splicing abnormalities linked to ALS, FTLD, and AD, including APP isoform disruption, across all three diseases.
- Open access
- 6 cites
Over 100 novel long noncoding RNAs respond specifically to Candida auris and its cell wall components in human PBMCs, especially after 24 hours of exposure.
- Open access
ZFP36L1, a zinc-dependent RNA-binding protein, suppresses hepatocyte senescence and ALD progression by destabilizing p21 and JAG1 mRNAs in mice and humans.
- Open access
- 1 cites
RNA polymerases II and III form dynamic, spatially distinct nuclear foci at the C. elegans 5S rDNA-SL1 gene cluster, with Pol II foci being temperature-sensitive.
- Open access
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Journals this month
- bioRxiv6131
- medRxiv1703
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3