Cancer-related Molecular Pathways

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TP53 status aligns with morphology and metaplastic programs in colorectal cancer organoids, and MDM2 P2 promoter usage reflects p53 activity
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753357
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BUB signaling in cancer and molecular insights into targeted therapies.
Communications Biology · 16 Oct 2026 · Review
Dysregulation of BUB gene family causes chromosomal instability linked to cancer progression, heterogeneity, metastasis, and therapy resistance.
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https://jclub.com.au/a/42888198
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Establishment of a doxycycline-inducible p16(INK4a) knock-in human embryonic stem cell line, WAe009-A-3Y.
Stem cell research · 9 Oct 2026 · Journal Article
A doxycycline-inducible p16 INK4a knock-in human embryonic stem cell line was established, showing dose-dependent p16 INK4a and ZsGreen expression upon induction.
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https://jclub.com.au/a/42880101
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Ref(2)P/p62 protein pleomorphism confers tissue-specific function
bioRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.01.10.696886
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A novel adenovirus 19K/IX protein enhances infection by attenuating proteasomal degradation of tyrosine-ubiquitinated capsid protein IX
bioRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.24.720336
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Direct CDK1 engagement underlies carbaryl-induced genotoxic cell cycle arrest
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.01.756001
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CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.
Cancer Research · 2 Oct 2026 · Journal Article
CDK2 inhibitor PF-07104091 achieves disease stabilization in CDK4/6 inhibitor-resistant HR+/HER2- metastatic breast cancer regardless of RB status, with responses linked to TP53 retention.
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https://jclub.com.au/a/42391342
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A breakthrough in p53-targeted therapy.
Nature Cancer · 1 Oct 2026 · Journal Article
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https://jclub.com.au/a/42823505
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FANCD2 knockdown suppresses malignant phenotypes and is associated with caspase/PARP-mediated apoptosis in NCI-H2052 pleural mesothelioma cells.
Frontiers in Genetics · 23 Sept 2026 · Journal Article
FANCD2 knockdown significantly suppresses proliferation and promotes apoptosis in NCI-H2052 pleural mesothelioma cells, involving caspase/PARP-mediated pathways.
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https://jclub.com.au/a/42841130
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Extended role of p21 during the exit from p21-induced G0/G1 arrest
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.23.630045
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Computational prioritization of candidate TCDD-associated targets in retinoblastoma using network toxicology and transcriptomic analysis.
Frontiers in Genetics · 9 Sept 2026 · Journal Article
Eighteen candidate TCDD-associated targets, including five hub genes, were identified in retinoblastoma, with CDK1 showing the strongest link to cell-cycle dysregulation.
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https://jclub.com.au/a/42775123
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The impact of chronic exposure to cigarette and waterpipe smoke extracts on telomeres, telomerase, and cancer progression.
Frontiers in Genetics · 9 Sept 2026 · Journal Article
Chronic exposure to cigarette and waterpipe smoke extracts causes telomere shortening and increases telomerase activity, promoting cancer progression in lung, colon, and breast cancer cells.
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https://jclub.com.au/a/42775372
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The role of cell growth rate on accumulation of the mitotic cyclin Cdc13 in fission yeast
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.14.724355
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Microtubule depolymerization at kinetochores restricts anaphase spindle elongation.
Nature Chemical Biology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/41617855
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Reining in immune responses with MDM2.
Nature Cell Biology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42717244
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Adaptive mechanisms and emerging cancer therapeutics for CDK2 inhibitors.
Nature Chemical Biology · 31 Aug 2026 · Review
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https://jclub.com.au/a/42675128
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p53 is a selective barrier to chromosome loss in cancer
bioRxiv · 25 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.07.04.663162
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