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HIV Research and Treatment

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Moved, week to 23 Oct 2026: 1
Papers in 60 days: 31

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The brain as an HIV reservoir: Recent findings using autopsy tissues from people with HIV.
PLOS Pathogens · 29 July 2026 · Review
HIV persists in brain tissues of virally suppressed individuals, with intact proviruses found in microglia and macrophages, challenging the notion of complete viral eradication.
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Structural Basis for Dimeric Genome Selection by HIV-1
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.17.732839
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A Tissue Virus Microenvironment with Activated Stress Responses Underlies Durable SIV Persistence
bioRxiv · 15 Oct 2026 · Preprint
Persistent SIV reservoirs in rhesus macaques are associated with a tissue microenvironment characterized by activated stress responses, metabolic rewiring, and immunosuppressive structures.
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https://jclub.com.au/a/10.64898/2026.04.02.716177
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Immunogenicity and Structure of a Stabilized HIV -1 clade C Env from a Pediatric Elite neutralizer in Complex with an Autologous bnAb
bioRxiv · 9 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.26.649701
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Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort.
Gut · 7 Oct 2026 · Observational Study
A broad, potent serum Fc-mediated effector function and neutralization profile is linked to protection against hepatitis C virus reinfection in high-risk MSM.
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https://jclub.com.au/a/41136184
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Structure-guided vaccination elicits broadly neutralizing antibodies targeting the HIV-1 silent face
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.30.755568
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Distinct allosteric remodeling of HIV-1 Env dynamics on virions by gp41-directed antibodies reveals two modes of neutralization.
eLife · 2 Oct 2026 · Journal Article
Most gp41-directed broadly neutralizing antibodies allosterically stabilize the prefusion-closed Env state, while the bivalent 10E8.4/iMab antibody favors both closed and open states.
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https://jclub.com.au/a/42826053
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Mechanisms of HIV-1 assembly, release and maturation.
Nature Reviews Microbiology · 1 Oct 2026 · Review
Advances in structural biology and imaging have revealed detailed mechanisms of HIV-1 assembly, release, and maturation, informing targeted antiviral strategies.
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https://jclub.com.au/a/42277315
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Finishing the fight against HIV.
Nature Microbiology · 29 Sept 2026 · Editorial
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https://jclub.com.au/a/42811104
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Deconvolution of HIV-1 Mutational Signatures Reveals Dominant and Donor-Specific APOBEC3-Associated Mutagenesis Across Anatomical Compartments
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.753842
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Human CD34⁺ progenitor-derived DC2 and DC3 subsets support CD169-mediated HIV-1 uptake
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.753077
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Stability of HIV RNA in plasma stored at different temperatures
medRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363748
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Efficacy of postmenopausal estrogen replacement in SIV-infected female macaques on antiretroviral therapy.
bioRxiv · 25 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.21.746440
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An altered B cell compartment distinguishes low antibody responders among people with HIV
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.18.26363407
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HIV-1 antibody-mediated neutralization via a dual-glycan clamp.
Cell Reports · 22 Sept 2026 · Journal Article
A novel Fab-dimerized glycan (FDG) antibody with a dual-glycan clamp epitope was isolated, showing approximately 30% breadth against HIV-1 and unique architecture.
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https://jclub.com.au/a/42690933
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Structural basis of lenacapavir-induced HIV-1 capsid defects during virion maturation.
Nature Communications · 22 Sept 2026 · Journal Article
Lenacapavir disrupts HIV-1 capsid maturation by altering interhexamer interactions, preventing functional cone-shaped capsid formation during virion assembly.
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https://jclub.com.au/a/42773142
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RNA-encoded PGT121-LS anti-HIV antibody: Comprehensive preclinical characterization and translational pharmacokinetics.
Molecular therapy. Nucleic acids · 17 Sept 2026 · Journal Article
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https://jclub.com.au/a/42894580
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Evidence for multiple prion conformers in natural scrapie isolates.
PLOS Pathogens · 17 Sept 2026 · Journal Article
Multiple prion conformers coexist within single natural scrapie isolates, with at least one previously unrecognized conformer identified through enhanced detection methods.
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https://jclub.com.au/a/42752506
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N4BP1 uses tandem KH domains to associate with EDC4 and mRNA decapping factors in P-bodies.
Communications Biology · 17 Sept 2026 · Journal Article
N4BP1 uses tandem KH domains to bind EDC4 and decapping factors, regulating mRNA decay and viral transcripts in P-bodies.
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https://jclub.com.au/a/42754686
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Priming of Multiple HIV Neutralizing B Cell Precursors in Humans
medRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.02.26352058
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Quantitative and amino acid sequence analysis of soluble HIV-1 Vpu and calmodulin interactions
bioRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.15.718738
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Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation, decomposes the viral core
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.19.649630
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Silent but persistent: Failure of continuous tenofovir based ART to prevent HBV and HDV reactivation under chemotherapy in an HBsAg-negative patient living with HIV.
Journal of hepatology · 2 Sept 2026 · Letter
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https://jclub.com.au/a/42685983
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Genomic Epidemiology of CHIKV During the Largest Outbreak in Mainland China-Implication for CHIKV Intervention
medRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.16.26355213
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Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery and enhanced humoral immune responses
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.29.728600
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Reining in immune responses with MDM2.
Nature Cell Biology · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42717244
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In vivo effect of anti-PD-1 on HIV-specific CD8+T-cells in men with HIV.
Nature Communications · 1 Sept 2026 · Journal Article
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https://jclub.com.au/a/42768041
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Design of optimized epigenetic regulators for durable gene silencing with application to PCSK9 in nonhuman primates.
Nature Biotechnology · 1 Sept 2026 · Journal Article
Optimized TALE-based epigenetic regulators achieve 98% gene silencing with durable effects over 343 days in primates.
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Serum HBsAg cannot distinguish cccDNA activity from integrated HBV DNA expression in chronic hepatitis B virus infection.
Journal of hepatology · 29 Aug 2026 · Journal Article
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https://jclub.com.au/a/42668120
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Sequential IL-15 and TGF-β1 stimulation expands reprogrammed CD103⁺CD39⁺ effector CD8⁺T cells and enhances HIV control
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.04.09.647906
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Larger inducible reservoir and higher abundance of exhausted CD8+ T cells in people treated after late versus non-late diagnosis of chronic HIV one year after ART initiation
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.31.715509
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