HIV persists in brain tissues of virally suppressed individuals, with intact proviruses found in microglia and macrophages, challenging the notion of complete viral eradication.
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PLOS Pathogens
Public Library of Science · Microbiology & Mycology · ISSN 1553-7366, 1553-7374
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Defective, transcriptionally active HIV-1 proviruses at specific genomic loci can reprogram CD4+ T cells toward proliferative, immune-evasive states during ART.
Venom vesicles from Ganaspis hookeri carry SERCA proteins into host immune cells, enabling immune suppression in Drosophila melanogaster larvae.
Arabidopsis deubiquitinases UBP12 and UBP13 are hijacked by CaMV to promote viral infection by altering host chromatin modifications.
HIV-1 compartmentalization between blood and cerebrospinal fluid occurs in PWH with cryptococcal meningitis, with some populations reaching over 10^5 copies/ml in CSF.
Structural analysis reveals mutations at residues 73 and 134 on VP3 mediate neutralization escape in O/Cathay FMDV variants, explaining antigenic drift.
The N-terminus of alpha-1 giardin is essential for oligomerization and lipid-binding activity in Giardia lamblia.
Intranasal HSV‑1 infection causes region-specific microglial remodeling dominated by interferon-driven regulatory programs in the CNS.
HCMV exploits host MORC2 to enhance DNA damage response on viral genomes, with MORC2 redistribution to viral replication compartments being essential for viral replication.
Intracellular SCARB2 mimicry with RMP(R8) broadly inhibits enteroviruses, overcoming extracellular decoy failure with potent antiviral activity and high safety in vitro and in vivo.
Downregulation of miRNA-1246 in healthy household contacts is linked to resistance to Mycobacterium tuberculosis infection.
Vaccination may accelerate influenza virus evolution and increase infection incidence unless specific conditions are met.
HCMV UL35 protein promotes proteasomal degradation of SLF2, disrupting SMC5/6 complex recruitment to PML nuclear bodies during infection.
GBP7 enhances HSV-1 infection by activating eEF1A1 through its GTPase activity, promoting protein translation and viral replication.
Zika virus produces two NS2A isoforms, with full-length NS2A necessary for replication and NS2Aα for virion assembly, playing mutually exclusive roles in the viral life cycle.
GL-reverted VH1-69 bnAbs recognize the E2 core domain in a manner similar to mature Abs, revealing conserved epitope engagement prior to affinity maturation.
AcNR1F regulates epidermal remodeling and host adaptation in Angiostrongylus cantonensis, with a 38.11% reduction in transcripts upon RNAi treatment.
Over 4000 genes are up-regulated during sporulation in P. infestans, with nitrogen limitation and cryptochrome-mediated light signals influencing the process.
VapC37 toxin in Mycobacterium tuberculosis selectively depletes tRNATrp, triggering Trp biosynthesis and increasing PDIM lipid production by over twofold.
Novel EG95-based mRNA-LNP vaccines induce durable immune responses and superior protection against Echinococcus granulosus in mice and lambs, with antibodies lasting over 12 months.
Distinct CAM binding site conformations are observed between assembly-active Cp150 capsids and assembly-inactive Cp149-Y132A structures of HBV core protein.
Pathogen-specific lncRNAs SSP7 and SSP8 are essential for fungal growth and virulence in Aspergillus fumigatus, revealing a novel regulatory mechanism.
Astroviruses use mucus secretion as a non-lytic pathway for viral egress in goblet cells.
Maternal antibodies, gut health, co-infections, and genetics collectively limit rotavirus vaccine effectiveness in low- and middle-income countries.
Exercise induces a hyperactivation-like state of the NLRP3 inflammasome, enhancing infection resistance by increasing cytokine secretion and reducing immune cell pyroptosis.
Trypanosoma brucei infection localizes in the uterine lining and causes immune and reproductive dysfunction in mice.
Receptor binding induces conformational changes in the MERS-CoV spike that weaken S1-S2 interactions and prime membrane fusion, revealing a structural pathway for activation.
Pore-forming toxin Monalysin is essential for Pseudomonas entomophila to suppress defecation in female Drosophila melanogaster, reducing pathogen expulsion and increasing virulence.
Glutamine is a major nitrogen source for Leptospira interrogans, supporting growth and proliferation in a human-like medium, and can be targeted to impair bacterial growth.
KSHV K15 M-genotype is linked to increased Kaposi sarcoma severity through heightened inflammation and edema in patients from Xinjiang, China.
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Topics moving, week to 23 Oct 2026
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- Alzheimer's disease research and treatments3
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