Neuroscience and Neuropharmacology Research

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Latest in Neuroscience and Neuropharmacology Research

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Multi-timescale dynamics organize descending pain modulation
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.15.693905
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Increased CA3 burst activity in Doc2α and Syt7 knockout mice
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.01.735713
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Hippocampus-evoked polysynaptic responses in the medial prefrontal cortex are attenuated in aged rats.
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.05.730244
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Mouse Neural Organoids Model the Mature In Vivo Synaptic Proteome
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.753785
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The Intermediate CA1 and CA3 Subfields of the Hippocampus Differentially Encode Social Recognition
bioRxiv · 22 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.27.684580
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Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination.
eLife · 21 Oct 2026 · Journal Article
Stable threat-value coding persists in prelimbic cortex populations despite 30 days of ensemble turnover during fear learning and retrieval in mice.
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https://jclub.com.au/a/42904408
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Multiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex.
eLife · 20 Oct 2026 · Journal Article
A transcriptional switch from KLF activators to repressors during early postnatal development regulates neuronal maturation in the mouse neocortex.
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https://jclub.com.au/a/42899467
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Dynamic recruitment of PV interneurons in the somatosensory cortex induced by experience dependent plasticity
bioRxiv · 19 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.27.662081
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Retuning ventral hippocampal output improves social memory and reduces anxiety-related behavior in temporal lobe epilepsy
bioRxiv · 16 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.12.675815
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Enzyme-Constrained Metabolic Modeling of the Tripartite Synapse Links Astrocyte-Neuron Lactate Shuttle to Lipid Trafficking and Redox Homeostasis
bioRxiv · 16 Oct 2026 · Preprint
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Astrocytic Nonsense-mediated mRNA decay regulates calcium signaling to support synapse function and influence anxiety-like behavior
bioRxiv · 16 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.11.18.689044
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Midbrain somatostatin-expressing cells control pain-suppression during defensive states
bioRxiv · 15 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2022.01.20.476899
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TDP2-mediated DNA repair regulates the dynamics of neuronal early response gene transcription and cortical neuron connectivity.
Cell Reports · 15 Oct 2026 · Journal Article
TDP2-mediated DNA repair is essential for timely regulation of early response gene transcription in cortical neurons, with Tdp2 deletion causing ERG overexpression and circuit dysfunction.
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https://jclub.com.au/a/42879281
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C. elegans GPCR kinase GRK-1 maintains behavioral persistence in a dynamic thermal environment.
EMBO Reports · 14 Oct 2026 · Journal Article
Loss of C. elegans GRK-1 reduces isothermal tracking duration by affecting neuronal states in RIM and AVA interneurons.
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Development of a genetically encoded fluorescent indicator for monitoring GPR52 activation
bioRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.11.711017
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Dorsal striatal astrocytes link dopamine to slow behavioral dynamics
bioRxiv · 14 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.12.01.626240
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Proprioceptive sensory-driven mechanisms shape Clarke's column development.
Cell Reports · 13 Oct 2026 · Journal Article
Proprioceptive sensory neurons are essential for the postnatal development and organization of Clarke's column neurons in the spinal cord.
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https://jclub.com.au/a/42873640
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Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly.
eLife · 13 Oct 2026 · Journal Article
Rab5 and Rab11 regulate distinct developmental events in neural circuit assembly through endocytic trafficking pathways.
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https://jclub.com.au/a/42868010
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Reduced dorsal CA1 activity limits retention of the temporal component of declarative memory in the Cntnap2 knockout mouse model of autism.
eLife · 13 Oct 2026 · Journal Article
Reduced dorsal CA1 activity in Cntnap2 knockout mice impairs long-term retention of temporal associations in declarative memory.
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https://jclub.com.au/a/42867479
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Synaptic vesicle undocking induces low-frequency depression.
eLife · 12 Oct 2026 · Journal Article
Low-frequency depression (LFD) at mammalian synapses results from synaptic vesicle undocking, not depletion of the readily releasable pool, and is immediately reversible by high-frequency stimulation.
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https://jclub.com.au/a/42862892
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Investigating molecular and hemodynamic effects of LSD in the human brain.
Nature Neuroscience · 12 Oct 2026 · Journal Article
LSD occupies 5-HT2AR with high affinity and increases global cerebral blood flow and internal carotid artery flow in humans.
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Synaptic connectome of a neurosecretory network in the Drosophila brain.
eLife · 12 Oct 2026 · Journal Article
Synaptic connectome analysis reveals diuretic hormone 44-expressing NSCs as key coordinators of physiology and behavior in the adult Drosophila brain.
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The dentate gyrus controls hippocampal representational drift
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.05.674488
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Upregulation of Calbindin in Adult Inhibitory Neurons Reactivates Critical Period Plasticity in Mouse Visual Cortex
bioRxiv · 10 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.07.08.737337
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Synaptic input architecture of visual cortical neurons revealed by large-scale synapse imaging without backpropagating action potentials
bioRxiv · 9 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.24.619996
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Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling.
eLife · 9 Oct 2026 · Journal Article
Starvation causes a near-complete suppression of heat-evoked reversals in Caenorhabditis elegans by altering AWC neuron responses and neuropeptide signaling.
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PTEN Subcellular Localization Dictates Function
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.16.732743
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Cell-intrinsic regulation of presynaptic release site patterning
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.10.02.756300
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Neuropathic pain drives time-dependent reorganization of naturalistic movement and corticostriatal circuits
bioRxiv · 8 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.07.680927
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Impaired astrocytic Cx43 syncytial network in lateral habenula affects synaptic connectivity and drives adolescent stress-induced depression
bioRxiv · 8 Oct 2026 · Preprint
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