Neural signaling's role in tumor progression varies with context, influenced by tumor kinetics, tissue structure, and immune interactions, highlighting a complex, adaptable system.
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Cancer, Stress, Anesthesia, and Immune Response
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Advances in surgical planning and molecular understanding are expanding the resectability of liver cancers, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
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Piezo2-expressing neurons and glial cells initiate early macrophage activation, driving inflammation in postoperative ileus in mice.
Replication stress in cancer is linked to genomic instability and tumor progression, with ATR-CHK1 pathway playing a key role in preventing catastrophic genome fragmentation.
Adult intracranial arteries supply Ntn4, a neurovascular factor critical for maintaining specific sympathetic neurons, with Ntn4 decline linked to neuronal loss in mice.
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Intratumoral sotigalimab combined with pembrolizumab induces a 50% objective response rate in metastatic melanoma, activating immune cells in both injected and non-injected tumors.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
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- Bacteriophages and microbial interactions5
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- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
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