Notch activation silences Hedgehog signaling via an E2-E3-E3 ubiquitin ligase module to specify germline stem cell niche in Drosophila ovary.
- Open access
Hedgehog Signaling Pathway Studies
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OCRL deficiency in Lowe syndrome causes mitochondrial dysfunction, impaired cilia-related Sonic Hedgehog signaling, and disrupted neuronal differentiation across multiple models.
- Open access
Aminopeptidase N acts as a receptor for hedgehog merbecoviruses, with species-specific use and a unique glycoprotein-receptor interface revealed by cryo-EM.
- Open access
Cilia beating of ependymal cells maintains adult neural stem cell quiescence through PKD1/2-TRPM3-mediated mechanical forces, with brief inhibition activating stem cells in vivo.
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