Elevated ABCA1 expression in the substantia nigra is linked to cholesterol overload and neurodegeneration in Parkinson's disease mouse models and postmortem brains.
Cholesterol and Lipid Metabolism
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PDE5A inhibitors, including sildenafil, induce lysosomal cholesterol accumulation and reduce metastasis in cancer models by disrupting NPC1-mediated cholesterol trafficking.
- Open access
VGLL4 promotes MAFLD progression by enhancing PDK4 transcription, with hepatocyte-specific overexpression inducing steatosis and knockout protecting mice from metabolic dysfunction.
- Open access
Zonated cholesterol sensing by SIRT2 initiates MASLD-related hepatocellular carcinoma, with SIRT2 overexpression in zone 1 causing tumors in mice and humans.
Targeting PID1 in tumor-associated macrophages produces oxysterols that reprogram macrophages toward an antitumor phenotype, enhancing immune responses in multiple cancers.
Familial hypercholesterolemia affects both homozygous and heterozygous individuals, requiring tailored assessment, diagnosis, and management strategies.
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Topics moving, week to 23 Oct 2026
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