Melanoma and MAPK Pathways
Moving in bioRxiv, Cancer Research, Nature Medicine, Cancer Discovery, Cell Reports, Nature Cancer, Nature Communications and Nature Reviews Cancer.
- Moved, week to 23 Oct 2026
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Latest in Melanoma and MAPK Pathways
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Five-year survival rates with neoadjuvant immune checkpoint inhibitors reach up to 87.5% in melanoma patients, especially among those achieving major pathological response.
- Open access
MutationProjector, a pre-trained genomic model, predicts therapeutic resistance and sensitivity across multiple cancer types with performance matching or exceeding state-of-the-art methods.
- Open access
A pediatric patient-derived xenograft (PDX) program created 388 models across 40+ diagnoses, including ultra-rare tumors, enabling detailed cancer biology and therapy studies.
Single-cell technologies reveal how genotypes and phenotypes co-evolve in human tissues, uncovering mutant-specific traits and therapeutic vulnerabilities in cancer.
Spatial analysis uncovers that melanoma transition involves a 3-fold increase in proliferation, metabolic changes, and microenvironment remodeling in nevus-associated melanomas.
DYP688, an antibody-drug conjugate targeting PMEL with a Gq/11 inhibitor payload, shows promising activity in GNAQ/GNA11-mutant melanomas with a 19.7% response rate.
- Open access
Small-molecule inhibitors targeting RAS/RAF disrupt allosteric RAF conformation, effectively treating diverse RAS-driven cancers with a broad-spectrum approach.
- Open access
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Topics moving, week to 23 Oct 2026
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