Proteomic profiling reveals that the (p)ppGpp-mediated stringent response in Pseudomonas aeruginosa regulates over 339 proteins during stationary phase, highlighting extensive metabolic shutdown and stress adaptation.
- Open access
Enzyme Structure and Function
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MKLN1 within the CTLH E3 ligase recognizes diverse substrates through multimodal engagement of acetylated, Arg, and C-degrons, revealing a versatile recognition mechanism.
- Open access
- 1 cites
HDOCK-Multimer (HDM) significantly outperforms existing methods in predicting large protein complex structures across multiple benchmarks.
- Open access
LoL-align is significantly more sensitive than TM-align and Dali in detecting remote homologs, with 5-20 times faster alignment speed on benchmark datasets.
- Open access
Human glutamine synthetase forms product-stabilized filaments that reduce catalytic specificity at physiological glutamine levels.
- Open access
Integrating protein structural context enables 96.5% accurate prediction of resistance-conferring mutations in M. tuberculosis proteins.
- Open access
AI-assisted and structure-guided methods now enable identification of PET-degrading enzymes with industrial relevance, surpassing traditional bioprospecting approaches.
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Topics moving, week to 23 Oct 2026
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