Malignant cells depend on NAD metabolism, especially via NAMPT, to support proliferation, stress tolerance, and immune evasion, revealing a potential therapeutic vulnerability.
Sirtuins and Resveratrol in Medicine
Moving in Cell Metabolism.
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Photo-downregulation of SIRT4 in aged mice increases H3K9ac levels by activating fatty acid metabolism, thereby mitigating cellular aging.
- Open access
α-Synuclein reduces triacylglycerols and disrupts lipid droplets and mitochondria in aging Caenorhabditis elegans, linking lipid metabolism to toxicity.
- Open access
Zonated cholesterol sensing by SIRT2 initiates MASLD-related hepatocellular carcinoma, with SIRT2 overexpression in zone 1 causing tumors in mice and humans.
Proteome-wide profiling reveals 17,102 lysine β-hydroxybutyrylation sites in Reynoutria japonica, linking Kbhb to plant stress response and metabolism regulation.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
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- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3
