Wnt/β-catenin signaling in development and cancer

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LIN28B is a post-transcriptional regulator of Wnt signalling in myeloid leukemia cells and dual targeting promotes cytotoxicity
bioRxiv · 19 Oct 2026 · Preprint
LIN28B interacts with β-catenin and regulates Wnt signaling through post-transcriptional modulation in myeloid leukemia cells.
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https://jclub.com.au/a/10.64898/2026.01.25.698240
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Notch-dependent left-right asymmetry in β-catenin-TCF activity instructs anteroposterior positioning of motor neurons in the C. elegans ventral nerve cord
bioRxiv · 18 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.03.02.641079
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Addendum: Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche.
Nature Medicine · 9 Oct 2026 · Journal Article
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https://jclub.com.au/a/42855585
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Carmn sustains basal stemness in exocrine glands and CTND1-mediated Wnt signaling in mammary tissue.
EMBO Reports · 8 Oct 2026 · Journal Article
Carmn is a conserved regulator of epithelial basal-cell stemness and Wnt/β-catenin signaling in exocrine glands, essential for tumor formation in mammary tissue.
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https://jclub.com.au/a/42850414
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Identification of Transcriptional Hippo Response Signature Connecting Inflammatory Bowel Disease and Colorectal Cancer Progression
medRxiv · 26 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.24.26363887
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Epithelial-mesenchymal Wnt crosstalk directs planar cell polarity in the developing cochlea.
Nature Communications · 16 Sept 2026 · Journal Article
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https://jclub.com.au/a/42881149
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Density-Dependent Rearrangement of Desmoplakin in Epithelial Junctions: Insights from Expansion Microscopy
bioRxiv · 16 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.30.721849
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Jag2 patterns early differentiation in the epidermal stem cell layer
bioRxiv · 11 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.02.28.708758
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Slap restricts oncogenic Src-family kinase signaling to maintain colonic epithelial homeostasis.
eLife · 8 Sept 2026 · Journal Article
SLAP suppresses EPHB2-SFK signaling, preventing excessive colonic epithelial proliferation and tumor development, highlighting its role as a tumor suppressor in the colon.
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https://jclub.com.au/a/42709470
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β-catenin controls Afadin cortical recruitment to regulate planar epithelial cell division
bioRxiv · 5 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.23.684278
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Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.
Cell · 3 Sept 2026 · Journal Article
A four-dimensional molecular map of hair follicle organogenesis reveals dynamic developmental processes in neonatal mouse skin.
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https://jclub.com.au/a/42385701
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Glycolytic suppression of cell adhesion promotes thyroid morphogenesis in response to nutrition.
EMBO Reports · 1 Sept 2026 · Journal Article
Glycolytic activity suppresses cell adhesion, promoting thyroid morphogenesis in Xenopus tadpoles, with a 50% increase in follicle formation under glycolytic conditions.
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https://jclub.com.au/a/42477468
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Zasp52's differentially expressed intrinsically disordered region confers thin filament stability at the Z-disc.
eLife · 27 Aug 2026 · Journal Article
Zasp52's intrinsically disordered region is essential for thin filament stability at the Z-disc in Drosophila muscle, with deletion causing flightlessness and structural defects.
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https://jclub.com.au/a/42657781
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Cell cycle-coupled CK1δ turnover, autoinhibition, and activity
bioRxiv · 26 Aug 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.18.712569
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