Cardiomyopathy and Myosin Studies
Moving in bioRxiv, Frontiers in Genetics, eLife, Stem cell research, Circulation, Communications Biology, Genome Medicine and Nature Communications.
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Latest in Cardiomyopathy and Myosin Studies
Newest first · last 60 days
Inhibiting IL-8-CXCR1 signaling reverses hypertrophic cardiomyopathy and fibrosis in Noonan syndrome models.
- Open access
A human iPSC line from a male HCM patient with a heterozygous TPM1 c.644C>T mutation exhibits normal karyotype and differentiation potential.
- Open access
A heterozygous missense variant c.391C>T (p.Arg131Cys) in FHL2 is linked to endocardial thickening in a 30-day-old infant with severe dilated cardiomyopathy.
- Open access
Confinement force microscopy reveals that cells respond to spatial confinement with a two-phase stress increase involving passive compression and active contractility.
- Open access
Post-prandial Burmese pythons show increased myofibril tension and relaxation rates, with frequent feeding linked to slower myofibril activation, indicating significant cardiac remodeling.
- Open access
Ferroptosis-related transcriptomic patterns in dilated cardiomyopathy are donor- and context-dependent, with no evidence for ferroptosis as a causal mechanism in primary hypertensive heart disease.
- Open access
Profilin enhances lamellipodium protrusion by regulating the balance between capping protein and VASP, crucial for actin network formation in cell migration.
- Open access
Stochastic heterogeneity and dynamic instability in sarcomeres enable robust cardiomyocyte contraction despite mechanical constraints, with 85 kPa stiffness revealing significant heterogeneity.
- Open access
- 1 cites
Zasp52's intrinsically disordered region is essential for thin filament stability at the Z-disc in Drosophila muscle, with deletion causing flightlessness and structural defects.
- Open access
Pangenome-based workflow GRAF achieves higher accuracy (F1 0.86) in detecting large pathogenic variants (≥20 bp) from targeted sequencing in cardiomyopathy cases.
- Open access
Sarcopenia independently increases the risk of diabetic cardiomyopathy by 2.25 times in patients with type 2 diabetes mellitus.
- Open access
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