RNA-triggered chromatin shredding using Cas12a2 can selectively eliminate tumor cells with mutations in TP53, MYC, and other difficult-to-drug cancer genes in mouse models.
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Human Argonaute 2 fused to a C-to-U deaminase achieves 1.9-fold higher targeted RNA editing in HEK293T cells compared to Cas13-based editors.
- Open access
A decade after their discovery in 2016, base editors have evolved into versatile tools used in clinical trials for multiple human diseases, including sickle cell disease and leukaemias.
cPRIME enables endogenous mapping of genetic variant effects at RNA level, revealing that synonymous marker edits can alter RNA processing in diverse genomic contexts.
- Open access
A modular lentiviral system enables multiplexed gene perturbation revealing hormone receptor interdependence in breast cancer growth in vivo.
- Open access
A human iPSC line carrying a de novo PHF21A variant was generated from an infant with epileptic spasms syndrome, providing a new model for studying the disease.
- Open access
CRISPR/Cas9 editing successfully corrected the LRRK2 I1371V mutation in a Parkinson's disease patient-derived iPSC line, creating an isogenic control line with confirmed genetic integrity.
- Open access
Adenine base editing successfully generated a PKP2 c.1171-2 A>G mutant human embryonic stem cell line, WAe009-A-3W, with preserved pluripotency and normal karyotype.
- Open access
Gene editing created isogenic USH2A-RP patient-derived iPSC lines with both homozygous and heterozygous corrections of the c.2276G > T mutation.
- Open access
A human induced pluripotent stem cell line from a Kabuki syndrome 1 patient with a frameshift KMT2D mutation was established, enabling disease modeling.
- Open access
Highly efficient retron-based gene editors for mammalian cells and vertebrates achieve editing levels comparable to conventional methods using a genetically encoded cassette.
- 7 cites
CAR T cells targeting surface U5 snRNP200, an RNA helicase absent from normal hematopoietic precursors, show efficacy against AML and B-cell ALL in models.
- Open access
CRISPR/Cpf1 editing of DNM1L in human iPSCs produces a mutant line with normal morphology, stability, and differentiation capacity.
- Open access
De novo RNA-guided transposition systems using TnpB-family proteins achieve high-efficiency DNA insertion with orientation control in bacteria.
- Open access
Genomic and transcriptomic qualification of patient-derived dopaminergic neuron precursors was successfully demonstrated across multiple donors for an autologous iPSC-based therapy for Parkinson's disease.
- Open access
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3