Vascularized human stem cell-derived islet organoids (VPIOs) exhibit improved β cell maturation and restore long-term normoglycemia in diabetic mice.
Cell Stem Cell
Elsevier BV · Cell & Molecular Biology · ISSN 1934-5909, 1875-9777
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Inhibition of GSK3B reduces lipid droplet accumulation and improves myelination in APOE4 oligodendrocytes and mouse models, highlighting GSK3B as a therapeutic target.
Layer-specific skin fibroblasts contribute to wound repair with distinct spatiotemporal patterns across wound severities.
PrimeCAR, a 2-day manufacturing strategy with low-intensity priming, enhances CAR-T cell fitness and limits inflammatory programming in a phase 1 study.
Single-cell CRISPR screening in human HSPCs identified regulators like SMYD3 and PRDM10 linked to cell fate and AML dependency, with 322 regulators profiled in 172,382 cells.
Hippo-controlled Igf2 expression is linked to postnatal liver growth and regeneration, highlighting a key regulatory mechanism.
Phagocytosis-shielded BaEVRLess-pseudotyped lentiviral vectors achieve up to 8.8% gene marking in humanized mice, with chemoselection enriching to 70% of HSCs for SCD therapy.
Genomic and transcriptomic qualification of patient-derived dopaminergic neuron precursors was successfully demonstrated across multiple donors for an autologous iPSC-based therapy for Parkinson's disease.
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Endothelialized callus organoids enable rapid regeneration of critical-size tibial defects in mice.
PD-L1/2-null TumorDressed dendritic cells significantly enhance T cell activation and cytotoxicity against primary hematologic and solid tumors in vitro and in vivo.
H3K27M-mutant diffuse midline gliomas maintain OPC stemness through dysregulated ACTIVIN signaling, which can be targeted by intrathecal therapy.
A patient-derived brainstem glioma organoid platform reveals Activin B-ACVR2A signaling promotes DMG growth and suggests a triple intrathecal therapy for inhibition.
Transformer base editing of HBG1/2 promoters was successfully applied across diverse β-hemoglobinopathies, including sickle cell disease and various β-thalassemia genotypes, in four patients.
Base editing treatment achieved transfusion independence and durable fetal hemoglobin expression in four patients with diverse β-hemoglobinopathies, including an African SCD patient.
Antibody-engineered lipid nanoparticles achieve efficient and durable in vivo editing of hematopoietic stem cells in humanized mice, advancing gene therapy for blood diseases.
ASO-tagged siRNA can enter the human CNS and may improve SOD1 lowering in ALS patients.
SNP-guided epigenetic repression of mutant alleles can induce compensatory expression from non-targeted alleles, maintaining gene dosage in dominant genetic disorders.
Hippo-IGF2 signaling axis regulates organ growth and can restore liver regeneration in aged mice, with Igf2 expression linked to organ size control.
Epi-Allele induces compensatory expression of non-targeted alleles, maintaining total gene expression and preventing haploinsufficiency in dominant genetic diseases.
Immunoids incorporating mature and immature immune populations are emerging as vital models for studying human immune-tissue interactions.
Engineered MSCs detect tumor stiffness to enable targeted radiotheranostics, achieving sensitive detection and treatment across multiple tumor models.
Ovarian aging drives systemic aging through cellular defects and hormonal decline, with interventions showing potential to extend healthspan and preserve fertility.
Human iPSC-derived valve-like assembloids replicate key features of human valve development and disease, providing a new platform for in vitro studies.
TIGRa, a compact and multiplexable gene activator, achieves efficient activation of up to 12 genes and reprograms human cells with less than half the size of traditional systems.
Organized pathological hematopoiesis occurs in the myelofibrotic spleen, involving complex cellular and stromal remodeling, challenging the idea of simple compensation.
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Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
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