Extracellular vesicles in disease

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Synaptic vesicle undocking induces low-frequency depression.
eLife · 12 Oct 2026 · Journal Article
Low-frequency depression (LFD) at mammalian synapses results from synaptic vesicle undocking, not depletion of the readily releasable pool, and is immediately reversible by high-frequency stimulation.
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https://jclub.com.au/a/42862892
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Towards a systematic understanding of the diverse subtypes, biogenesis and functions of large extracellular vesicles.
Nature Reviews Molecular Cell Biology · 5 Oct 2026 · Review
Most large extracellular vesicles (lEVs) exceeding 200 nm originate from the plasma membrane and include diverse subtypes with distinct biogenesis pathways.
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Multi-omic profiling defines subtype-specific extracellular vesicle signatures in early human pregnancy
bioRxiv · 5 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.10.710888
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Mechanochemically-reprogrammed stem cell exosomes reconcile the biogenesis internalization trade-off for pulmonary fibrosis therapy
bioRxiv · 3 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.03.20.713315
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Fecal extracellular vesicles from adults with autism spectrum disorder affect mouse behavior and gut motility by targeting the neuronal nitrergic pathway
bioRxiv · 2 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.28.754921
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Systemic health impact of cancer-associated extracellular vesicles and particles.
Nature Reviews Cancer · 1 Oct 2026 · Review
Cancer-associated extracellular vesicles and particles are linked to widespread systemic dysfunction across multiple organs, contributing to host morbidity and mortality.
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Engineering bispecific exosome activators of T cells to target immune checkpoint inhibitor-resistant metastatic melanoma.
Nature Biotechnology · 1 Oct 2026 · Journal Article
Inhalable BEAT exosomes co-displaying PD-1 and FZD8 activate T cells and produce robust antitumor effects in ICI-resistant melanoma mouse models.
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https://jclub.com.au/a/41491256
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Single molecule detection of Tau seeds in extracellular vesicles from Alzheimer's disease brains
bioRxiv · 25 Sept 2026 · Preprint
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Increased extracellular fluid viscosity drives M2-like macrophage polarization to promote breast cancer progression and immunotherapy resistance.
Cell Reports · 24 Sept 2026 · Journal Article
Elevated extracellular fluid viscosity in the tumor microenvironment promotes M2-like macrophage polarization, breast cancer growth, metastasis, and resistance to immunotherapy.
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Circulating extracellular vesicle lipidomics identifies distinct signatures of amyotrophic lateral sclerosis and spinal muscular atrophy
medRxiv · 24 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.23.26363372
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Epithelial-endothelial barrier dysfunction and oxidative stress in ARDS subphenotypes: comparative efficacy of extracellular vesicles derived from bone marrow (MSC-EVs) and adipose tissue (ASC-EVs) mesenchymal stem cells
medRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.09.22.26363677
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Clostridium butyricum-derived extracellular vesicles alleviate ETEC K88-induced intestinal injury by regulating Wnt/β-catenin signaling and gut microbiota.
Applied and environmental microbiology · 23 Sept 2026 · Journal Article
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CNN-based learning of single-cell transcriptomes reveals a blood-detectable multi-cancer signature of brain metastasis
bioRxiv · 23 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.03.08.584083
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Small Extracellular Vesicles from Gram-Negative Bacterial Infections Induce Myeloid Differentiation via p38 Signaling and Coordinate Antibacterial Defense Through the p38-IL-6 Axis
bioRxiv · 21 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.30.697125
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Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis
bioRxiv · 17 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.06.16.659944
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Extracellular membrane vesicles-previously unrecognized components of Staphylococcus aureus biofilms.
Journal of bacteriology · 17 Sept 2026 · Journal Article
Membrane vesicles (MVs) are generated within Staphylococcus aureus biofilms and serve as carriers of key matrix components, contributing to biofilm formation.
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A nanoscale atlas of extracellular vesicles and particles in Drosophila olfactory sensilla
bioRxiv · 16 Sept 2026 · Preprint
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Transparent Weighting of Heterogeneous Evidence for Auditable Candidate Prioritization
bioRxiv · 15 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.14.725271
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Platelets promote acute liver injury via extracellular vesicles-mediated Aldolase A
bioRxiv · 14 Sept 2026 · Preprint
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Effect of seminal plasma extracellular vesicles in post-thaw functional parameters of cryopreserved ram sperm
bioRxiv · 9 Sept 2026 · Preprint
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EVd3x: A Bioinformatics Platform for Evidence-aware Interpretation of EV Cargo
bioRxiv · 9 Sept 2026 · Preprint
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Multi-modal microRNA and non-targeted proteome analysis of liquid biopsies from the distal lung collected by Particles in Exhaled Air (PExA) reveal presence from extracellular vesicles
bioRxiv · 7 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.12.620657
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Myogenic differentiation-derived small extracellular vesicles as a therapeutic strategy for miR-193b-3p-mediated muscle regeneration.
Molecular therapy. Nucleic acids · 3 Sept 2026 · Journal Article
Small extracellular vesicle-delivered miR-193b-3p enhances muscle regeneration by suppressing AP2M1 in vitro and in a murine muscle loss model.
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Bacterial Stimulation Remodels Macrophage Extracellular Vesicle Lipids and Reveals iNOS as an Inflammatory Cargo
bioRxiv · 2 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2025.12.11.693607
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VDisk: A Microfluidic Cartridge for Automated and Reproducible Label-Free Isolation of Extracellular Vesicles from Plasma
bioRxiv · 29 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.04.674190
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