BRCA gene mutations in cancer
Moving in medRxiv, Frontiers in Genetics, The Lancet Oncology, bioRxiv, EMBO Journal, EMBO Reports, The American Journal of Human Genetics and The Lancet.
- Moved, week to 23 Oct 2026
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- Papers in 60 days
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Latest in BRCA gene mutations in cancer
Newest first · last 60 days
Brca1 coiled-coil domain mutants retain the ability to suppress Group 1 tandem duplications in mouse cells and tumor models despite impaired homologous recombination functions.
- Open access
Pathogenic variants in 2.73% of the Slovenian population are found in 84 medically actionable genes, with an additional 0.48% of novel likely pathogenic variants.
- Open access
Expanding cancer susceptibility testing beyond genetics clinics to the general population requires a careful, context-specific approach due to uncertain evidence for many genes and risk scores.
- 1 cites
Access to cancer genomics and precision oncology remains profoundly unequal across and within countries, leaving millions without guideline-indicated interventions annually.
- 10 cites
Interaction between BRCA1 exon 11 and TOPBP1 is essential for DNA end-resection during homologous recombination.
- Open access
Multi-cancer gene panels identify pathogenic variants in 4.8% of individuals not meeting testing criteria, missing 22% of actionable hereditary cancer cases.
- Open access
European Health Data Space and biobanking integration could create a trustworthy, federated health research infrastructure in Europe, but faces significant governance and technical challenges.
- Open access
Sixty-two percent of transgender adults are willing to participate in genomics research, but concerns about harm and mistrust remain significant barriers.
- Open access
Effective communication behaviors in clinical encounters can enhance trust and improve participation of underrepresented populations in biobanking, as shown by preliminary findings.
- Open access
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