Retinal Development and Disorders
Moving in bioRxiv, Stem cell research, eLife, Nature Communications, Frontiers in Genetics, Cell Reports, EMBO Reports and Environmental pollution.
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Latest in Retinal Development and Disorders
Newest first · last 60 days
Single-cell spatial transcriptomics uncovers broad and focal organization of degeneration responses in LCA5 mouse retinas, revealing localized injury and stress patterns.
- Open access
Model-based fMRI with large-field stimulation and retinotopic atlas reliably maps contrast sensitivity across the visual field, even with fixation variability, in seven participants.
- Open access
Gene editing created isogenic USH2A-RP patient-derived iPSC lines with both homozygous and heterozygous corrections of the c.2276G > T mutation.
- Open access
Viral delivery of PRPF31 restores splicing, cellular function, and visual activity in patient-derived retinal cells, even in mature stages, offering a promising therapy for RP11.
- Open access
Two recurrent founder alleles account for 39.2% of EYS variants in an Eastern European and Northern Asian cohort with retinitis pigmentosa.
- Open access
Retinal waves, apoptosis, and angiogenesis are tightly synchronized during postnatal mouse retinal development, with apoptotic cells triggering neural activity and vascular growth.
- Open access
The pulvinar primarily relays signals from V1 to V2 in macaques, with V1 activity leading pulvinar and pulvinar leading V2, supporting a feedforward communication role.
- Open access
Bhlhe22 and Kappa Opioid Receptor-expressing wide-field amacrine cells in mouse retina encode stimulus orientation with Ca2+ signals aligned to dendritic structure.
- Open access
- 6 cites
Synergistic inhibition of Notch signaling and forced cell cycle re-entry induces significant Müller glia reprogramming, generating diverse retinal neuron-like cells in uninjured mouse retina.
- Open access
Humans and models match in discriminating visual features with pooling windows scaled to about one-fourth in luminance compared to spectral energy across large stimuli.
- Open access
Calcium inhibits viral channelrhodopsins by binding near the retinal cofactor, blocking essential conformational changes and preventing ion translocation.
- Open access
rAAV-mediated delivery of multiple miRNAs targeting MAPK signaling suppresses laser-induced choroidal neovascularization in mice by reducing CNV leakage and angiogenesis.
- Open access
Mapping variants to genes in ocular cells reveals 80 candidate effector genes for primary open-angle glaucoma, highlighting ARHGEF12's role in disease mechanisms.
- Open access
- 1 cites
Hedgehog signaling drives exponential growth and neuronal production in the developing vertebrate retina by regulating neural progenitor cell cycles.
- Open access
- 1 cites
PIP2 binds at an allosteric site to inhibit human rod CNG channels by stabilizing closed states, preventing channel opening, as shown by cryo-EM structures.
- Open access
- 1 cites
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