Drug Transport and Resistance Mechanisms

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High-throughput glioblastoma-neurovascular assembloids model blood-tumor barrier disruption, tumor reprogramming and therapeutic efficacy
bioRxiv · 21 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.11.11.622979
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Publisher Correction: Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy.
Nature Microbiology · 16 Oct 2026 · Published Erratum
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Lambda-cyhalothrin exposure disrupts microbiota-associated bile acid metabolism and enterohepatic feedback in mice.
Environmental pollution · 15 Oct 2026 · Journal Article
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Lateral opening site of human oligopeptide transporter 2 plays a key role in the interaction with polymyxins
bioRxiv · 11 Oct 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.04.01.715775
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Recognition and mechanism of M. tuberculosis cell wall galactan transport.
Nature Communications · 9 Oct 2026 · Journal Article
Cryo-EM structures reveal how WzmWzt transporter binds and translocates mycobacterial lipid-linked galactan in M. tuberculosis, highlighting key conformational changes.
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https://jclub.com.au/a/42850284
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Use of genetic analysis in adult cholestatic liver disease: lessons from progressive paediatric syndromes and cohort studies.
Gut · 7 Oct 2026 · Review
Genetic variants in ABCB4, ABCB11, and ATP8B1 are linked to a spectrum of adult and paediatric cholestatic liver diseases, including PFIC types 1-3.
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https://jclub.com.au/a/42309808
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P4-ATPase BbCrpa2 detoxifies cyclosporine a via AP2-clathrin-dependent endocytic pathway in Beauveria bassiana.
Cell Reports · 6 Oct 2026 · Journal Article
BbCrpa2, a plasma membrane P4-ATPase in Beauveria bassiana, is a key determinant of CsA resistance by mediating its endocytic internalization with 100% dependence on AP2-clathrin pathways.
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Selected plasma-associated molecular species remodel the ABCB1 linker with effects retained under structure-derived tethering
bioRxiv · 4 Oct 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.08.13.670033
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Relieving IBD with duvakitug.
Nature reviews. Gastroenterology & hepatology · 1 Oct 2026 · Journal Article
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Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment.
Nature Chemical Biology · 1 Oct 2026 · Journal Article
HEP-50768, a potent and selective inverse agonist of MRGPRX4, suppresses bile-acid-induced pruritic behaviors in humanized rats, indicating its potential for cholestatic itch treatment.
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https://jclub.com.au/a/41957282
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Spatial distribution of blood-brain barrier membrane proteins is controlled by sorting motifs and physiological signals in vivo
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.05.10.724157
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Small-molecule inhibitors block NorA efflux by conformational trapping.
Nature Chemical Biology · 16 Sept 2026 · Journal Article
IMP-2380 effectively inhibits the NorA efflux pump in Staphylococcus aureus, restoring antibiotic susceptibility with low-nanomolar potency and structural trapping of the transporter.
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Analysis of the off-target interaction of amyloid PET tracers with human brain sulfotransferases
bioRxiv · 9 Sept 2026 · Preprint
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https://jclub.com.au/a/10.64898/2026.06.16.732640
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Efficacy and safety of duvakitug in patients with ulcerative colitis (RELIEVE UCCD): a phase 2b, randomised, placebo-controlled trial.
The lancet. Gastroenterology & hepatology · 1 Sept 2026 · Randomized Controlled Trial
Duvakitug significantly improved clinical remission rates in patients with moderate to severe ulcerative colitis, with response rates of up to 48% at week 14.
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Cellular and signalling mechanisms that regulate the blood-brain barrier.
Nature Reviews Molecular Cell Biology · 1 Sept 2026 · Review
Molecular regulators and cell interactions make the blood-brain barrier a dynamic, highly selective interface crucial for CNS health and disease.
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Elafibranor in primary biliary cholangitis: Two-year placebo-controlled outcomes and long-term open-label data from the ELATIVE® phase III trial.
Journal of hepatology · 27 Aug 2026 · Journal Article
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Coordinated HNF4α and HNF4γ Suppression Defines a Reversible Ileal Epithelial Barrier Defect in Crohn,s Disease
bioRxiv · 27 Aug 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.10.27.684895
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