Pluripotent Stem Cells Research
Moving in Stem cell research, bioRxiv, Nature Biotechnology, Nature Communications, Nature Medicine, Cell Reports, Nature and Nature Chemical Biology.
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Latest in Pluripotent Stem Cells Research
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Spatial multi-omic atlas reveals distinct hepatocyte- and cholangiocyte-lineage programs and cardiac progenitors in a CS12 human embryo.
- Open access
Sequential activation of TPRX1 and HERVL defines the stepwise progression toward human 8-cell-like cells in vitro.
- Open access
PUS7-mediated pseudouridylation of 7SK enhances human somatic cell reprogramming efficiency and chromatin accessibility.
- Open access
- 1 cites
A human iPSC line carrying a de novo PHF21A variant was generated from an infant with epileptic spasms syndrome, providing a new model for studying the disease.
- Open access
CRISPR/Cas9 editing successfully corrected the LRRK2 I1371V mutation in a Parkinson's disease patient-derived iPSC line, creating an isogenic control line with confirmed genetic integrity.
- Open access
A doxycycline-inducible p16 INK4a knock-in human embryonic stem cell line was established, showing dose-dependent p16 INK4a and ZsGreen expression upon induction.
- Open access
Two human iPSC lines modeling mucopolysaccharidosis types IIIA and I with specific pathogenic variants were generated from KOLF2.1J cells.
- Open access
A human iPSC line from a SPG46 patient with compound heterozygous GBA2 variants was successfully generated and characterized.
- Open access
Adenine base editing successfully generated a PKP2 c.1171-2 A>G mutant human embryonic stem cell line, WAe009-A-3W, with preserved pluripotency and normal karyotype.
- Open access
Inducible hiPSC lines with controlled Progerin expression enable modeling of cellular aging, with successful integration confirmed by PCR and sequencing.
- Open access
A human iPSC line from a male HCM patient with a heterozygous TPM1 c.644C>T mutation exhibits normal karyotype and differentiation potential.
- Open access
A human iPSC line from an asymptomatic woman carrying the GAA c.2051C>A (p.P684Q) variant was successfully generated, exhibiting typical stem cell features and differentiation capacity.
- Open access
Ageing reflects progressive decanalization of mammalian cell identity driven by erosion of a regulatory grammar established during development, with most age-related DNA methylation gain occurring at PRC2-bound regions.
Eleven high-quality human iPSC clones from four donors were generated and extensively validated for genetic stability and pluripotency.
- Open access
A human induced pluripotent stem cell line from a nephronophthisis patient with NPHP4 variants exhibits pluripotency and differentiation capacity.
- Open access
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Topics moving, week to 23 Oct 2026
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