Temperature-dependent increases in motor neuron activity partially compensate for muscle contraction loss in the crab Cancer borealis at high temperatures, but cannot prevent failure.
- Open access
Ion channel regulation and function
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Mammalian BK channels with ~250 pS conductance are more efficient and precise in neuronal activation than invertebrate channels with lower conductance.
- Open access
Two human iPSC lines from HypoPP patients carrying the CACNA1S c.1583G>A (p.Arg528His) mutation were generated and characterized for research use.
- Open access
Intracellular Zn 2+ directly inhibits mouse Slo3 potassium channels in a dose-dependent manner at micromolar concentrations, with slow dissociation, during sperm capacitation.
- Open access
Ca V 2.1 calcium-dependent facilitation is essential for reliable auditory information transfer, with a 37% reduction in postsynaptic firing precision when absent.
- Open access
Spatial proteomics reveals FXYD6 as a dual-site protein at the neuromuscular junction in the diaphragm, with significant enrichment in type IIa fibers.
- Open access
LRRC8A/D heteromeric channels are activated by cell swelling and modulated by sybodies, with a specific structure of four A and two D subunits revealing key conformational states.
- Open access
Mutations in the intracellular subdomain of LRRC8A cause constitutive activation of VRAC channels, highlighting its role as a key regulatory hub.
- Open access
- 1 cites
PRRT2 enhances Nav channel slow inactivation and delays recovery, affecting neuronal excitability from zebrafish to humans.
- Open access
Lamprey KCNE0, an early-diverging KCNE family member, induces constitutive KCNQ1 activity, highlighting its unique role in vertebrate ion channel regulation.
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