FluEmbed predicts influenza A (H3N2) antigenic drift with high accuracy, achieving a Spearman correlation of 0.67-0.80 from RNA sequences without alignments.
- 1 cites
PLOS Computational Biology
Public Library of Science · Genomics & Bioinformatics · ISSN 1553-734X, 1553-7358
- Impact (2-yr)
- 4.7
- h-index
- 282
- Open access
- 100%
- Works
- 13.1K
- Papers this month
- 67
Track PLoS Comput Biol in JClubFree on iPhone and Android · in the app, the list is My Journals
Rebuilt
Moved this week
Latest in PLoS Comput Biol
Newest first · last 60 days
Development of concise, repeatable reporting appraisal tools is essential for peer review and editorial assessment of research manuscripts.
CLIMB and CLIFF accurately deconvolve bulk RNA-seq data into cell-type and drug sensitivity profiles, outperforming existing methods in multiple cancer contexts.
Weak dispersal and larger landscape size promote local species richness in heterogeneous metacommunities of competing species.
Spatially-targeted malaria interventions in Madagascar show that targeting central communities improves resource efficiency but does not eliminate malaria.
Implementing and sustaining genomics capacity in the Global South requires human-centered approaches, strategic planning, and equitable collaboration, as outlined by ten simple rules.
A constraint-first framework enables reliable, auditable, and accountable AI-driven genome design across diverse life forms and viruses.
CtDToolkit provides synthetic datasets and metrics that reflect neural computation, enabling more accurate modeling of neural dynamics in systems neuroscience.
MEGH-DDI achieves 98.36% accuracy in drug-drug interaction prediction on the DrugBank dataset, surpassing previous methods and achieving over 99.7% AUC and AP.
TCR repertoire differences in the spleen during immune responses are mainly driven by compartment size and proliferation, not TCR sequence features, according to a Galton-Watson model.
Interpretable neural networks identify cancer driver genes from genome-wide dependency landscapes, recovering major drivers and highlighting candidates with broad functional footprints.
Receptor architecture determines mechanical persistence, with domain-swapped GPVI showing greater force resistance than reconstructed GPVI and CLEC-2 during separation.
Extended phase mapping explicitly detecting phase defects improves identification of rotational drivers in cardiac arrhythmias across simulated, experimental, and clinical data.
DipSkmer provides more accurate estimates of genetic diversity (θ) for diploid genome skims, outperforming existing methods like Mash and Skmer at low genetic distances.
Attenuated renewal process models outperform alternatives in forecasting mpox outbreaks within MSM sexual networks, achieving more balanced and reliable predictions.
Coccus-like bacterial cells more effectively invade and fixate in communities than bacillus cells, with fixation times estimated by a drift-diffusion model in simulations.
NKG2D receptor signaling kinetics in NK cells vary by cell cycle stage, with the largest CD107a upregulation observed in G2+M phase.
Preferred stimulus direction in cat V1 is reversed with changing temporal frequency in over half of the cortex, revealing four distinct map motifs.
Human letter identification is more impaired by cortical scrambling (CS) than subcortical scrambling (SCS), with higher relative efficiency for CS in CNN comparisons.
Sparse neuronal C4 overexpression in about 2% of prefrontal cortex neurons induces widespread transcriptomic and lipid-droplet remodeling in the cortical microenvironment.
A Transformer model predicts cancer cell fate from raw video sequences with 94% accuracy, identifying predictive signals up to 8 hours before cell outcomes.
Antimony 3 extends support for SBML Level 3 Core and FBC, enabling combined kinetic and flux balance models within a human-readable format.
Hypermutational processes can explain the dominance of weak, atypical KRAS driver mutations in POLE-mutant colorectal cancers, with mutation bias and rate playing key roles.
Process Bigraph enables effective integration of diverse biological processes in multiscale models, demonstrated by spatially organized microbial ecosystem simulations.
A novel axonal deformation damage model accurately reproduces neuro-electrophysiological responses under various stretching conditions, capturing sodium left-shift phenomena.
People distort explicit source reliability in decision-making but retain some awareness of its influence, with unreliable sources biasing choices even when labeled as such.
Ant colonies modulate departure and return rates of foragers to activate reserve workers, which stabilizes colony energetics and scales with colony size.
Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model, with five distinct firing regimes produced by the model.
DyME enables high-throughput MD-based mutagenesis and comparative analysis of protein recognition mimicry, handling thousands of molecular systems simultaneously.
Effective funding pitches in grant applications should focus on content, structure, and scientific argumentation to convince reviewers of project excellence and researcher suitability.
Embedded Feedback Controller (EFC) achieves <1% residual error in calibrating paediatric cardiovascular models across normal and septic shock phenotypes.
Track PLoS Comput Biol in JClub
Browse JClub
Journals this month
- bioRxiv6131
- medRxiv1703
- PNAS447
- Sci Adv354
- JAMA262
- Environ Res230
- BMJ182
- Environ Pollution165
- Nat Commun161
- Science141
- Nature138
- Lancet128
- Cell Rep120
- NEJM119
- mBio107
- Plant Cell Environ107
- Curr Biol106
- J Exp Bot106
Topics moving, week to 23 Oct 2026
- Single-cell and spatial transcriptomics6
- Neuroinflammation and Neurodegeneration Mechanisms5
- Bacteriophages and microbial interactions5
- Gut microbiota and health5
- Genomics and Phylogenetic Studies4
- Cancer Genomics and Diagnostics4
- Cancer Immunotherapy and Biomarkers4
- Alzheimer's disease research and treatments3
- Inflammatory Bowel Disease3
- Influenza Virus Research Studies3